UC

Contacto

Dra. Luz OPPLIGER

comunicaciones@bio.puc.cl

BIOLOGÍA CELULAR Y MOLECULAR

BRANDAN ,ENRIQUE

Enrique Brandan Enrique Brandan

Laboratorio: 6862725
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Sitio Web: http://www.brandan.cl/


Profesor Titular

Laboratorio de Diferenciación Celular y Patología

BIOLOGÍA CELULAR Y MOLECULAR,
Facultad de Ciencias Biológicas,
Pontificia Universidad Católica de Chile, Alameda 340, Santiago

Antecedentes Académicos

Bioquímica, University of Massachusetts (1989).
Bioquímica, Saint Louis University (1987).
Doctor (en Ciencias Biológicas, con mención en Biología Celular) , Pontificia Universidad Católica de Chile (1985).
Licenciado, Universidad de Chile (1979).

Postdoctorado:

E.A. Doisy Department of Biochemistry St. Louis University  (1986-1987); Department of Biochemistry, University of Massachusetts (1987-1988)

Especialización:

Biología Celular, Diferenciación Celular, Matriz Extracelular y Miogénesis.

Premios y Distinciones

  • Mejor Académico 2007, Federación de Estudiantes Universidad Católica (FEUC) (2007).
  • Miembro Correspondiente, Academia Chilena de Ciencias (2007).

Actividades de Docencia

Pregado
  • 2018 BIO141C-1, Biologia De La Celula.
  • 2017 BIO141C-1, Biologia De La Celula.
  • 2016 BIO141C-1, Biologia De La Celula.
Postgrado
  • 2018 BIO4040-1, Bases Celulares Y Moleculares De Las Patologías.
  • 2017 BIO4040-1, Bases Celulares Y Moleculares De Las Patologías.
  • 2016 BIO4040-1, Bases Celulares Y Moleculares De Las Patologías.

Líneas de Investigación

1.    Matriz extracelular y diferenciación.

El objetivo general de nuestra investigación es entender como la matriz extracelular (MEC) regula la diferenciación muscular esquelética. La diferenciación muscular está controlada por un conjunto complejo de interacciones entre los mioblastos y su entorno. La presencia de la MEC es esencial para la miogénesis normal. La MEC interactúa con la célula muscular a través de integrinas y alteraciones en éstas se traduce en distrofias musculares.

2.    Regulación de la diferenciación muscular por factores de crecimiento.

Existen moléculas denominadas proteoglicanes, los cuales son constituyentes de la matriz extracelular y la membrana plasmática. Nosotros hemos demostrado que tanto sindecán-1 y -3 regulan de manera positiva la presentación del factor de crecimiento FGF-2 a sus receptores transductores. Por el contrario, el proteoglicán glipicán secuestra FGF-2 de lo receptores al concentrase en balsas lipídicas. Estos mecanismos son esenciales para modular la biogénesis o formación del músculo esquelético.

3.    Decorina un proteoglicán con capacidad de inhibir factores de crecimiento pro-fibróticos.

El factor de crecimiento de tipo transformante b y el de crecimiento de tejido conectivo (CTGF) son dos factores que estimulan la síntesis de matriz extracelular (MEC). Este aumento de MEC es característico de la fibrosis, la cual se encuentra en la gran mayoría de las enfermedades crónicas como por ejemplo fibrosis renal, cardíaca, hepática, pulmonar y muscular, siendo ésta última asociada a las distrofias musculares como la distrofia muscular de Duchenne. Hemos encontrado que el proteoglicán decorina es capaz de inhibir a ambos factores, a través de regiones diferentes en la molécula de decorina. En la actualidad poseemos un fragmento de 11 amino ácidos el cual inhiben la señalización dependiente de TGF-b y LRP-1. Por otro parte hemos identificado una región de 22 amino ácidos que inhibe los efectos biológicos mediados por CTGF.

4.  El sistema renina-angiotensina (RAS) un regulador positivo y negativo de la fibrosis     muscular esquelética.

También estamos evaluando péptidos presentes en RAS, como angiotensina II y angiotensina 1-7, en su capacidad de estimular o inhibir la fibrosis. Estamos determinando en cultivos celulares a través de que rutas de señalización estos péptidos afectan la síntesis de la matriz extracelular. In vivo, infusión continua de estos péptidos o antagonistas de los receptores de éstos, aumentan o inhiben la fibrosis en modelos animales de distrofia muscular como el ratón mdx. Además estamos estudiando la función de la enzima ACE2, encargada de generar angiotensina 1-7 y su receptor Mas, en los mecanismos involucrados en la regulación de la fibrosis asociada a las distrofias musculares.

5.    El factor de crecimiento de tejido conectivo CTGF, factor clave en la generación de fibrosis muscular y cardíaca.

Estamos estudiando la función del factor de crecimiento de tejido conectivo (CTGF) en la generación de la fibrosis muscular presente en las distrofias musculares. Hemos generado animales distróficos (mdx) los cuales son heterocigotos para el factor CTGF (mdx-CTGF /-). Estos ratones presentan una fibrosis disminuida y menor daño muscular en respuesta al ejercicio. Por otra parte la sobre-expresión de CTGF, a través de un adenovirus especifico para el factor, induce fibrosis y daño muscular. DE igual forma la fibrosis cardíaca presente en el ratón mdx está disminuida en ratones mdx-CTGF /- . Estamos evaluando como el aumento o la disminución de la fibrosis afecta la función cardíaca. De igual forma estamos evaluando la inhibición de CTGF a través de anticuerpos contra el factor (Colaboracion con Fibrogen, USA). El efecto de estos anticuerpos es inhibir la fibrosis mediada por CTGF y aumentar la fuerza muscular.

6.    Productos naturales inhibidores de la fibrosis.

Estamos evaluando un extracto de una planta, el cual presenta fuerte actividad inhibitoria del factor pro-fibrótico CTGF. Ratones distróficos tratados con esta droga botánica presentan una fibrosis disminuida y una mejor capacidad muscular determinada a través de ensayos funcionales en el animal y determinaciones electrofisiológicas en músculos aislados.

7.    Terapia celular y fibrosis.

Existen avances importantes en terapia celular para restaurar la expresión de proteínas defectivas presentes en las distintas distrofias musculares. Sin embargo, estas terapias celulares son parcialmente exitosas debido fundamentalmente al exceso de fibrosis presentes en el músculo esquelético distrófico. Estamos evaluando en los diferentes modelos animales, en los cuales hemos disminuido la fibrosis muscular, si la terapia celular es más exitosa. Para ella fibras musculares aisladas y/o células satélites progenitoras de músculo esquelético, son transplantados a músculos de estos animales y la capacidad de revertir el fenotipo distrófico es evaluado. Además estamos estudiando si el medio ambiente fibrótico afecta la capacidad de las células progenitoras a colonizar músculos distróficos.


Titulo: Characterization Of The Molecular Mechanism Underlying The Role Of Mirystic, Palmitic, Palmitoleic Acid As Beneficial Signaling Molecules In The Heart
Año: 2015
Concurso e institución: Regular, CONICYT
Investigador principal: Riquelme Illanes Cecilia
Otros investigadores: Riquelme Illanes Cecilia, Brandan Siques Enrique, Gatica Arnaldo
Fecha inicio: 01-03-2015
Fecha termino: 01-03-2019
Duración: 48 meses

Titulo: Participation Of Mesenchymal Progenitors In The Initiation Of Skeletal Muscle Fibrosis: Effect Of Tgfbeta/ctgf/pdgf And Co-Factors On Fibroblasts’ Ability To Modulate Myogenesis
Año: 2015
Concurso e institución: Regular, CONICYT
Investigador principal: Brandan Siques Enrique
Otros investigadores: Brandan Siques Enrique, Casar Leturia Juan Carlos, Olguin Marin Hugo Cesar
Fecha inicio: 01-03-2015
Fecha termino: 01-03-2019
Duración: 48 meses

Titulo: Role Of Mitochondria Fusion Proteins Opa-1 And Mfn2 Specific Mutations, In The Pathogenesis Of Mitochondrial Diseases.
Año: 2015
Concurso e institución: Regular, CONICYT
Investigador principal: Eisner Sagues Veronica Raquel
Otros investigadores: Eisner Sagues Veronica Raquel, Brandan Siques Enrique
Fecha inicio: 01-03-2015
Fecha termino: 01-03-2019
Duración: 48 meses

Titulo: El Factor Del Respuesta A Hipoxia Hif-1 Es Un Mediador De La Fibrosis Muscular A Través De La Activación De Ctgf: Estudios En Modelos De Distrofia Muscular Y En Daño Inducido Por Denervación
Año: 2013
Concurso e institución: Postdoctorado, CONICYT
Investigador principal: Rebolledo Lpez Daniela Victoria
Otros investigadores: Rebolledo Lopez Daniela Victoria, Brandan Siques Enrique
Fecha inicio: 01-11-2013
Fecha termino: 01-11-2016
Duración: 36 meses

Titulo: Post-Translation Control Of Transcription Factor Pax7 And The Regulation Of Mucle Pogenitor Cell Fate
Año: 2013
Concurso e institución: Regular, CONICYT
Investigador principal: Olguin Marin Hugo Cesar
Otros investigadores: Olguin Marin Hugo Cesar, Brandan Siques Enrique
Fecha inicio: 01-03-2013
Fecha termino: 01-03-2017
Duración: 48 meses

Titulo: Anti-Atrophic Role Of Angiotensin 1-7 On Skeletal Muscle
Año: 2012
Concurso e institución: Regular, CONICYT
Investigador principal: Cabello Verrugio Claudio
Otros investigadores: Cabello Verrugio Claudio, Brandan Siques Enrique
Fecha inicio: 01-03-2012
Fecha termino: 01-02-2016
Duración: 47 meses

Titulo: Development Of Polymeric Scaffold For Muscle Tissue Engineering And Repair
Año: 2011
Concurso e institución: Interdisciplina, UC
Investigador principal: Olguin Marin Hugo Cesar
Otros investigadores: Olguin Marin Hugo Cesar, Valenzuela Roediger Loreto Margarita, Brandan Siques Enrique
Fecha inicio: 01-11-2011
Fecha termino: 01-11-2013
Duración: 24 meses

Titulo: Novel Antifibrotic Role Of The Ace2/angiotensin 1-7/mas Axis In Skeletal Muscular Dystrophies
Año: 2011
Concurso e institución: Regular, CONICYT
Investigador principal: Brandan Siques Enrique
Otros investigadores: Brandan Siques Enrique
Fecha inicio: 01-03-2011
Fecha termino: 01-03-2015
Duración: 48 meses

Titulo: Ctgf The Factor Involved In Fibrosis Development In Dmd
Año: 2008
Concurso e institución: , Otro
Investigador principal: Brandan Siques Enrique
Otros investigadores: Brandan Siques Enrique, Fadic Ruiz Ricardo Julio Nicolas, Cabello Verrugio Claudio Alejandro
Fecha inicio: 01-03-2008
Fecha termino: 01-03-2011
Duración: 36 meses

Titulo: Droga Botánica (Botanical Drug Para La Fda De Eeuu) Para El Tratamiento En Enfermedades Crónicas Asociadas A Fibrosis De Alta Incidencia Nacional Y Mundial
Año: 2008
Concurso e institución: Investigación Y Desarrollo, CONICYT
Investigador principal: Brandan Siques Enrique
Otros investigadores: Brandan Siques Enrique
Fecha inicio: 01-02-2008
Fecha termino: 01-02-2011
Duración: 36 meses

Titulo: Dmd Fibrosis: Role Of Ctgf, Lrp And Proteoglycans (Mda 3790)
Año: 2004
Concurso e institución: , Otro
Investigador principal: Brandan Siques Enrique
Otros investigadores: Brandan Siques Enrique
Fecha inicio: 01-01-2004
Fecha termino: 01-01-2007
Duración: 36 meses

Titulo: Function Of Proteoglycans During Skeletal Muscle Formation
Año: 2003
Concurso e institución: , Otro
Investigador principal: Brandan Siques Enrique
Otros investigadores: Brandan Siques Enrique
Fecha inicio: 01-01-2003
Fecha termino: 01-01-2008
Duración: 60 meses


Publicaciones ISI

1
Andrographolide Ameliorates Inflammation And Fibrogenesis And Attenuates Inflammasome Activation In Experimental Non-Alcoholic Steatohepatitis
Autor(es): Daniel Cabrera, Alexander Wree, Davide Povero, Nancy Solis, Alejandra Hernandez, Margarita Pizarro, Han Moshage, Javiera Torres, Ariel E. Feldstein, Claudio Cabello-Verrugio, Enrique Brandan, Francisco Barrera, Juan Pablo Arab, Marco Arrese
Año: 2017.7:1-12.10.1038/s41598-017-03675-z
Ref: Daniel Cabrera, Alexander Wree, Davide Povero, Nancy Solis, Alejandra Hernandez, Margarita Pizarro, Han Moshage, Javiera Torres, Ariel E. Feldstein, Claudio Cabello-Verrugio, Enrique Brandan, Francisco Barrera, Juan Pablo Arab, Marco Arrese. Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis. Scientific Reports. 2017;7(3491):1-12.

2
Connective Tissue Cells Expressing Fibro/adipogenic Progenitor Markers Increase Under Chronic Damage: Relevance In Fibroblast-Myofibroblast Differentiation And Skeletal Muscle Fibrosis
Autor(es): Contreras O, Rebolledo D, Oyarzun J, Olguin H, Brandan E
Año: 2016.364:647-660.
Ref: Contreras O, Rebolledo D, Oyarzun J, Olguin H, Brandan E. Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell And Tissue Research. 2016;364(3):647-660.

3
Wnt Signaling Pathway Improves Central Inhibitory Synaptic Transmission In A Mouse Model Of Duchenne Muscular Dystrophy
Autor(es): Fuenzalida M, Espinoza C, Perez M, Tapia C, Cuitino L, Brandan E, Inestrosa N
Año: 2016.86:109-120.
Ref: Fuenzalida M, Espinoza C, Perez M, Tapia C, Cuitino L, Brandan E, Inestrosa N. Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Neurobiology Of Disease. 2016;86(-):109-120.

4
Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated With Sarcopenia And Decreased Serum Insulin-Like Growth Factor-1
Autor(es): Cabrera D, Ruiz A, Cabello-Verrugio C, Brandan E, Estrada L, Pizarro M, Solis N, Torres J, Barrera F, Arrese M
Año: 2016.61:3190-3198.
Ref: Cabrera D, Ruiz A, Cabello-Verrugio C, Brandan E, Estrada L, Pizarro M, Solis N, Torres J, Barrera F, Arrese M. Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1. Digestive Diseases And Sciences. 2016;61(11):3190-3198.

5
Angiotensin-(1-7) Attenuates Disuse Skeletal Muscle Atrophy In Mice Via Its Receptor, Mas.
Autor(es): Morales Mg,, Abrigo J,, Acuna Mj,, Santos Ra,, Bader M,, Brandan E,, Simon F,, Olguin H,, Cabrera D,, Cabello-Verrugio C
Año: 2016.9:441-449.10.1242/dmm.023390
Ref: Morales MG,, Abrigo J,, Acuña MJ,, Santos RA,, Bader M,, Brandan E,, Simon F,, Olguin H,, Cabrera D,, Cabello-Verrugio C,. Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas.. Disease Models & Mechanisms. 2016;9:441-449.

6
Transforming Growth Factor Type-Beta Inhibits Mas Receptor Expression In Fibroblasts But Not In Myoblasts Or Differentiated Myotubes; Relevance To Fibrosis Associated To Muscular Dystrophies
Autor(es): Cofre C, Acuna M, Contreras O, Morales M, Riquelme C , Cabello C, Brandan E
Año: 2015.41:111-120.
Ref: Cofre C, Acuna M, Contreras O, Morales M, Riquelme C , Cabello C, Brandan E . Transforming growth factor type-beta inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies. Biofactors. 2015;41(2):111-120.

7
Angiotensins As Therapeutic Targets Beyond Heart Disease
Autor(es): Passos D, Brandan E, Santos R
Año: 2015.36:310-320.
Ref: Passos D, Brandan E, Santos R. Angiotensins as therapeutic targets beyond heart disease. Trends In Pharmacological Sciences. 2015;36(5):310-320.

8
Heparan Sulfate Provides A Mechanism To Respond To Fgfr2B And Control Regenerative
Autor(es): Brandan E.
Año: 2015.1:89-89.10.1007/s12079-015-0277-7
Ref: Brandan E.. Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative. Journal Of Cell Communication And Signaling. 2015;1(9):89-89.

9
Endotoxin-Induced Skeletal Muscle Wasting Is Prevented By Angiotensin-(1-7) Through A P38 Mapk-Dependent Mechanism
Autor(es): Morales M, Olguin H, Di Capua G, Brandan E , Simon F, Cabello C
Año: 2015.129:461-476.
Ref: Morales M, Olguin H, Di Capua G, Brandan E , Simon F, Cabello C. Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism. Clinical Science. 2015;129(6):461-476.

10
The Angiotensin-(1-7)/mas Axis Reduces Myonuclear Apoptosis During Recovery From Angiotensin Ii-Induced Skeletal Muscle Atrophy In Mice
Autor(es): Meneses C , Morales M, Abrigo J, Simon F, Brandan E, Cabello C
Año: 2015.467:1975-1984.
Ref: Meneses C , Morales M, Abrigo J, Simon F, Brandan E, Cabello C. The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice. Pflugers Archiv-European Journal Of Physiology. 2015;467(9):1975-1984.

11
Angiotensin-(1-7) Decreases Skeletal Muscle Atrophy Induced By Angiotensin Ii Through A Mas Receptor-Dependent Mechanism
Autor(es): Franco Cisternas, Maria Morales, Carla Meneses, Felipe Simon, Enrique Brandan, Johanna Abrigo, Yaneisi Vazquez, Claudio Cabello-Verrugio
Año: 2015.:307-319.10.1042/CS20140215
Ref: Franco Cisternas, Maria Morales, Carla Meneses, Felipe Simon, Enrique Brandan, Johanna Abrigo, Yaneisi Vazquez, Claudio Cabello-Verrugio. Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism. Clinical Science. 2015;(128):307-319.

12
Smad3 And Sp1/sp3 Transcription Factors Collaborate To Regulate Connective Tissue Growth Factor Gene Expression In Myoblasts In Response To Transforming Growth Factor
Autor(es): Cordova G, Rochard A, Riquelme C, Cofre C , Scherman D, Bigey P, Brandan E
Año: 2015.116:1880-1887.
Ref: Cordova G, Rochard A, Riquelme C, Cofre C , Scherman D, Bigey P, Brandan E. SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor. Journal Of Cellular Biochemistry. 2015;116(9):1880-1887.

13
Reck-Mediated Beta 1-Integrin Regulation By Tgf-Beta 1 Is Critical For Wound Contraction In Mice
Autor(es): Gutierrez J , Droppelmann C, Contreras O , Takahashi C, Brandan E
Año: 2015.10:1-20.
Ref: Gutierrez J , Droppelmann C, Contreras O , Takahashi C, Brandan E . RECK-Mediated beta 1-Integrin Regulation by TGF-beta 1 Is Critical for Wound Contraction in Mice. Plos One. 2015;10(8):1-20.

14
Ace2 Is Augmented In Dystrophic Skeletal Muscle And Plays A Role In Decreasing Associated Fibrosis
Autor(es): Riquelme C, Acuna M, Torrejon J, Rebolledo D, Cabrera D, Brandan E, Santos R
Año: 2014.9:1-12.
Ref: Riquelme C, Acuña M, Torrejón J, Rebolledo D, Cabrera D, Brandan E, Santos R. ACE2 is augmented in dystrophic skeletal muscle and plays a role in decreasing associated fibrosis. Plos One. 2014;9(4):1-12.

15
Glypican-1 Regulates Myoblast Response To Hgf Via Met In A Lipid Raft-Dependent Mechanism: Effect On Migration Of Skeletal Muscle Precursor Cells
Autor(es): Gutierrez J, Cabrera D, Brandan E
Año: 2014.4:1-16.
Ref: Gutiérrez J, Cabrera D, Brandan E. Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: Effect on migration of skeletal muscle precursor cells. Skeletal Muscle. 2014;4(1):1-16.

16
Novel And Optimized Strategies For Inducing Fibrosis In Vivo: Focus On Duchenne Muscular Dystrophy
Autor(es): Pessina P, Cabrera D, Morales M, Riquelme C, Gutierrez J, Serrano A, Brandan E, Mun&tild;oz-Canoves P
Año: 2014.4:1-17.
Ref: Pessina P, Cabrera D, Morales M, Riquelme C, Gutiérrez J, Serrano A, Brandan E, Mun&tild;oz-Ca´noves P. Novel and optimized strategies for inducing fibrosis in vivo: Focus on Duchenne Muscular Dystrophy. Skeletal Muscle. 2014;4(1):1-17.

17
Restoration Of Muscle Strength In Dystrophic Muscle By Angiotensin-1-7 Through Inhibition Of Tgf-Beta Signalling
Autor(es): Acuna, M, Pessina P, Olguin H, Cabrera D, Vio C, Cabello C, Brandan E, Et Al
Año: 2014.23:1237-1249.
Ref: Acuña, M, Pessina P, Olguin H, Cabrera D, Vio C, Cabello C, Brandan E, ET AL. Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling. Human Molecular Genetics. 2014;23(5):1237-1249.

18
Wnt Signaling In Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse And Fibrosis
Autor(es): Cisternas P, Brandan E, Inestrosa N, Henriquez J
Año: 2014.49:574-589.
Ref: Cisternas P, Brandan E, Inestrosa N, Henriquez J. Wnt signaling in skeletal muscle dynamics: Myogenesis, neuromuscular synapse and fibrosis. Molecular Neurobiology. 2014;49(1):574-589.

19
Andrographolide Attenuates Skeletal Muscle Dystrophy In Mdx Mice And Increases Efficiency Of Cell Therapy By Reducing Fibrosis
Autor(es): Cabrera D, Gutierrez J, Morales M, Brandan E, Cabello-Verrugio C, Mezzano S, Fadic R, Casar J, Hancke J
Año: 2014.4:1-15.
Ref: Cabrera D, Gutiérrez J, Morales M, Brandan E, Cabello-Verrugio C, Mezzano S, Fadic R, Casar J, Hancke J. Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis. Skeletal Muscle. 2014;4(1):1-15.

20
Transforming Growth Factor Type Beta 1 Increases The Expression Of Angiotensin Ii Receptor Type 2 By A Smad- And P38 Mapk-Dependent Mechanism In Skeletal Muscle
Autor(es): Painemal P, Acuna J, Riquelme C, Brandan E, Claudio Cabello-Verrugio
Año: 2013.39:467-475.
Ref: Painemal P, Acuna J, Riquelme C, Brandan E, Claudio Cabello-Verrugio. Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle. Biofactors. 2013;39(4):467-475.

21
Reducing Ctgf/ccn2 Slows Down Mdx Muscle Dystrophy And Improves Cell Therapy
Autor(es): Morales M, Gutierrez J, Cabrera D, Brandan E, Cabello-Verrugio C, Lipson K, Goldschmeding R
Año: 2013.22:4938-4951.
Ref: Morales M, Gutierrez J, Cabrera D, Brandan E, Cabello-Verrugio C, Lipson K, Goldschmeding R. Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Human Molecular Genetics. 2013;22(24):4938-4951.

22
Inhibition Of The Angiotensin-Converting Enzyme Decreases Skeletal Muscle Fibrosis In Dystrophic Mice By A Diminution In The Expression And Activity Of Connective Tissue Growth Factor (Ctgf/ccn-2)
Autor(es): Morales M, Cabrera D, Cespedes C, Vio C, Vazquez Y, Brandan E, Cabello C
Año: 2013.353:173-187.
Ref: Morales M, Cabrera D, Cespedes C, Vio C, Vazquez Y, Brandan E, Cabello C. Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2). Cell And Tissue Research. 2013;353(1):173-187.

23
Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model To Study The Early Phases Of Diabetic Cardiomyopathy
Autor(es): Calligaris S, Lecanda M, Solis F, Ezquer M, Gutierrez J, Brandan E, Leiva A, Sobrevia L, Conget P
Año: 2013.8:Art. e60931-..
Ref: Calligaris S, Lecanda M, Solis F, Ezquer M, Gutierrez J, Brandan E, Leiva A, Sobrevia L, Conget P. Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy. Plos One. 2013;8(4):Art. e60931-..

24
Role Of Skeletal Muscle Proteoglycans During Myogenesis
Autor(es): Brandan E, Gutierrez J
Año: 2013.32:289-297.
Ref: Brandan E, Gutierrez J. Role of skeletal muscle proteoglycans during myogenesis. Matrix Biology. 2013;32(6):289-297.

25
Role Of Proteoglycans In The Regulation Of The Skeletal Muscle Fibrotic Response
Autor(es): Brandan E, Gutierrez J
Año: 2013.280:4109-4117.
Ref: Brandan E, Gutierrez J. Role of proteoglycans in the regulation of the skeletal muscle fibrotic response. Febs Journal. 2013;280(17):4109-4117.

26
Angiotensin Ii Receptor Type 1 Blockade Decreases Ctgf/ccn2-Mediated Damage And Fibrosis In Normal And Dystrophic Skeletal Muscles
Autor(es): Cabello C , Morales M, Cabrera D , Vio C, Brandan E
Año: 2012.16:752-764.
Ref: Cabello C , Morales M, Cabrera D , Vio C, Brandan E . Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles. Journal Of Cellular And Molecular Medicine. 2012;16(4):752-764.

27
Angiotensin Ii-Induced Pro-Fibrotic Effects Require P38Mapk Activity And Transforming Growth Factor Beta 1 Expression In Skeletal Muscle Cells
Autor(es): Morales M, Vazquez Y, Acuna M, Rivera J, Simon F, Salas J, Ruf J, Brandan E , Cabello-Verrugio C
Año: 2012.44:1993-2002.
Ref: Morales M, Vazquez Y, Acuna M, Rivera J, Simon F, Salas J, Ruf J, Brandan E , Cabello-Verrugio C. Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells. International Journal Of Biochemistry & Cell Biology. 2012;44(11):1993-2002.

28
The Internal Region Leucine-Rich Repeat 6 Of Decorin Interacts With Low Density Lipoprotein Receptor-Related Protein-1, Modulates Transforming Growth Factor (Tgf)-Beta-Dependent Signaling, And Inhibits Tgf-Beta-Dependent Fibrotic Response In Skeletal Muscles
Autor(es): Cabello C , Santander C , Cofre C , Acuna M, Melo F, Brandan E
Año: 2012.287:6773-6787.
Ref: Cabello C , Santander C , Cofre C , Acuña M, Melo F, Brandan E. The Internal Region Leucine-rich Repeat 6 of Decorin Interacts with Low Density Lipoprotein Receptor-related Protein-1, Modulates Transforming Growth Factor (TGF)-beta-dependent Signaling, and Inhibits TGF-beta-dependent Fibrotic Response in Skeletal Muscles. Journal Of Biological Chemistry. 2012;287(9):6773-6787.

29
Fibrotic Response Induced By Angiotensin-Ii Requires Nad(P)H Oxidase-Induced Reactive Oxygen Species (Ros) In Skeletal Muscle Cells
Autor(es): Cabello C, Acuna M , Morales M , Becerra A , Simon F , Brandan E
Año: 2011.410:665-670.
Ref: Cabello C, Acuna M , Morales M , Becerra A , Simon F , Brandan E . Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells . Biochemical And Biophysical Research Communications. 2011;410(3):665-670.

30
Connective Tissue Growth Factor Induction By Lysophosphatidic Acid Requires Transactivation Of Transforming Growth Factor Type Beta Receptors And The Jnk Pathway
Autor(es): Cabello-Verrugio C , Cordova G , Vial C , Zuniga Lm, Brandan E
Año: 2011.23:449-457.
Ref: Cabello-Verrugio C , Cordova G , Vial C , Zuniga LM, Brandan E . Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type beta receptors and the JNK pathway. Cellular Signalling. 2011;23(2):449-457.

31
Ctgf/ccn-2 Over-Expression Can Directly Induce Features Of Skeletal Muscle Dystrophy
Autor(es): Morales M, Cabello C , Santander C , Cabrera D , Goldschmeding R, Brandan E
Año: 2011.225:490-501.
Ref: Morales M, Cabello C , Santander C , Cabrera D , Goldschmeding R, Brandan E. CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy. Journal Of Pathology. 2011;225(4):490-501.

32
Decorin Interacts With Connective Tissue Growth Factor (Ctgf)/ccn2 By Lrr12 Inhibiting Its Biological Activity
Autor(es): Vial C , Gutierrez J , Santander C , Cabrera D , Brandan E
Año: 2011.286:24242-24252.
Ref: Vial C , Gutierrez J , Santander C , Cabrera D , Brandan E . Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity . Journal Of Biological Chemistry. 2011;286(27):24242-24252.

33
Syndecan-4 And Beta 1 Integrin Are Regulated By Electrical Activity In Skeletal Muscle: Implications For Cell Adhesion
Autor(es): Ugarte G, Santander C, Brandan E
Año: 2010.29:383-392.
Ref: Ugarte G, Santander C, Brandan E. Syndecan-4 and beta 1 integrin are regulated by electrical activity in skeletal muscle: Implications for cell adhesion. Matrix Biology. 2010;29(5):383-392.

34
A Novel Mechanism Of Sequestering Fgf-2 By Glypican In Lipid Rafts, Allowing Skeletal Muscle Differentiation
Autor(es): Gutierrez J, Brandan E
Año: 2010.:1634-1649.
Ref: Gutiérrez J, Brandan E. A Novel Mechanism of Sequestering FGF-2 by Glypican in Lipid Rafts, Allowing Skeletal Muscle Differentiation. Molecular And Cellular Biology. 2010;(30):1634-1649.

35
Uptake Of Tritiated Liquids By Individual Breakfast Cereal Flakes
Autor(es): Medina W, Laurent S, Brandan E, Aguilera Jm
Año: 2010.75:E194-E200.
Ref: Medina W, Laurent S, Brandan E, Aguilera JM. Uptake of Tritiated Liquids by Individual Breakfast Cereal Flakes. Journal Of Food Science. 2010;75(3):E194-E200.

36
Tgf-Beta Receptors, In A Smad-Independent Manner, Are Required For Terminal Skeletal Muscle Differentiation
Autor(es): Droguett R, Cabello-Verrugio C, Santander C, Brandan E
Año: 2010.316:2487-2503.
Ref: Droguett R, Cabello-Verrugio C, Santander C, Brandan E. TGF-beta receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation. Experimental Cell Research. 2010;316(15):2487-2503.

37
Inhibition Of Extracellular Matrix Assembly Induces The Expression Of Osteogenic Markers In Skeletal Muscle Cells By A Bmp-2 Independent Mechanism
Autor(es): Osses N, Casar Jc, Brandan E
Año: 2009.10:73-73.
Ref: Osses N, Casar JC, Brandan E. Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism. Bmc Cell Biology. 2009;10:73-73.

38
Matrix Metalloproteinase-2-Deficient Fibroblasts Exhibit An Alteration In The Fibrotic Response To Connective Tissue Growth Factor/ccn2 Because Of An Increase In The Levels Of Endogenous Fibronectin
Autor(es): Droppelmann Ca, Gutierrez J, Vial C, Brandan E
Año: 2009.284:13551-13561.
Ref: Droppelmann CA, Gutiérrez J, Vial C, Brandan E. Matrix Metalloproteinase-2-deficient Fibroblasts Exhibit an Alteration in the Fibrotic Response to Connective Tissue Growth Factor/CCN2 because of an Increase in the Levels of Endogenous Fibronectin. Journal Of Biological Chemistry. 2009;284(20):13551-13561.

39
Skeletal Muscle Cells Express The Profibrotic Cytokine Connective Tissue Growth Factor (Ctgf/ccn2), Which Induces Their Dedifferentiation
Autor(es): Vial C, Zuniga L, Cabello-Verrugio C, Canon P, Fadic R, Brandan E
Año: 2008.27:435-441.
Ref: Vial C, Zúñiga L, Cabello-Verrugio C, Cañón P, Fadic R, Brandan E. Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation. Journal Of Cellular Physiology. 2008;27(4):435-441.

40
Heparin Activates Wnt Signaling For Neuronal Morphogenesis
Autor(es): Colombres M, Henriquez J, Reig G, Scheu J, Calderon R, Alvarez A, Brandan E, Inestrosa Nc
Año: 2008.216:805-815.
Ref: Colombres M, Henríquez J, Reig G, Scheu J, Calderón R, Álvarez A, Brandan E, Inestrosa NC. Heparin activates Wnt signaling for neuronal morphogenesis. Journal Of Cellular Physiology. 2008;216(3):805-815.

41
Novel Regulatory Mechanisms For The Proteoglycans Decorin And Biglycan During Muscle Formation And Muscular Dystrophy
Autor(es): Brandan E, Cabello-Verrugio C, Vial C
Año: 2008.27:700-708.
Ref: Brandan E, Cabello-Verrugio C, Vial C. Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy. Matrix Biology. 2008;27(8):700-708.

42
Ctgf Inhibits Bmp-7 Signaling In Diabetic Nephropathy
Autor(es): Nguyen T, Roestenberg P, Van Nieuwenhoven F, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles J, Vial C, Brandan E, Lyons K, Goldschmeding R
Año: 2008.19:2098-2107.
Ref: Nguyen T, Roestenberg P, Van Nieuwenhoven F, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles J, Vial C, Brandan E, Lyons K, Goldschmeding R. CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy. Journal Of The American Society Of Nephrology. 2008;19(11):2098-2107.

43
Adenovirus-Mediated Hepatic Syndecan-1 Overexpression Induces Hepatocyte Proliferation And Hyperlipidaemia In Mice
Autor(es): Cortes V, Amigo L, Donoso K, Valencia I, Quinones V, Zanlungo S, Brandan E, Rigotti A
Año: 2007.27:569-581.
Ref: Cortés V, Amigo L, Donoso K, Valencia I, Quiñones V, Zanlungo S, Brandan E, Rigotti A. Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice. Liver International. 2007;27(4):569-581.

44
A Novel Modulatory Mechanism Of Transforming Growth Factor-Ss Signaling Through Decorin And Lrp-1
Autor(es): Cabello-Verrugio C, Brandan E
Año: 2007.282:18842-18850.
Ref: Cabello-Verrugio C, Brandan E. A novel modulatory mechanism of transforming growth factor-ss signaling through decorin and LRP-1. Journal Of Biological Chemistry. 2007;282(26):18842-18850.

45
Transforming Growth Factor Beta (Tgf-Beta) Signaling Is Regulated By Electrical Activity In Skeletal Muscle Cells - Tgf-Beta Type I Receptor Is Transcriptionally Regulated By Myotube Excitability
Autor(es): Ugarte G, Brandan E
Año: 2006.281:18473-18481.
Ref: Ugarte G, Brandan E. Transforming Growth Factor Beta (Tgf-Beta) Signaling Is Regulated by Electrical Activity in Skeletal Muscle Cells - Tgf-Beta Type I Receptor Is Transcriptionally Regulated by Myotube Excitability. Journal Of Biological Chemistry. 2006;281(27):18473-18481.

46
Extracellular Proteoglycans Modify Tgf-Beta Bio-Availability Attenuating Its Signaling During Skeletal Muscle Differentiation
Autor(es): Droguett R, Cabello-Verrugio C, Riquelme C, Brandan E
Año: 2006.25:332-341.
Ref: Droguett R, Cabello-Verrugio C, Riquelme C, Brandan E. Extracellular Proteoglycans Modify Tgf-Beta Bio-Availability Attenuating Its Signaling During Skeletal Muscle Differentiation. Matrix Biology. 2006;25(6):332-341.

47
Increase In Decorin And Biglycan In Duchenne Muscular Dystrophy: Role Of Fibroblasts As Cell Source Of These Proteoglycans In The Disease
Autor(es): Fadic R, Mezzano V, Alvarez K, Cabrera D, Holmgren J, Brandan E
Año: 2006.10:758-769.
Ref: Fadic R, Mezzano V, Álvarez K, Cabrera D, Holmgren J, Brandan E. Increase in Decorin and Biglycan in Duchenne Muscular Dystrophy: Role of Fibroblasts As Cell Source of These Proteoglycans in the Disease. Journal Of Cellular And Molecular Medicine. 2006;10(3):758-769.

48
Betaglycan Induces Tgf-Beta Signaling In A Ligand-Independent Manner, Through Activation Of The P38 Pathway
Autor(es): Santander C, Brandan E
Año: 2006.18:1482-1491.
Ref: Santander C, Brandan E. Betaglycan Induces Tgf-Beta Signaling in a Ligand-Independent Manner, Through Activation of the P38 Pathway. Cellular Signalling. 2006;18(9):1482-1491.

49
Changes In Secreted And Cell Associated Proteoglycan Synthesis During Conversion Of Myoblasts To Osteoblasts In Response To Bone Morphogenetic Protein-2: Role Of Decorin In Cell Response To Bmp-2
Autor(es): Gutierrez J, Osses N, Brandan E
Año: 2006.206:58-67.
Ref: Gutiérrez J, Osses N, Brandan E. Changes in Secreted and Cell Associated Proteoglycan Synthesis During Conversion of Myoblasts to Osteoblasts in Response to Bone Morphogenetic Protein-2: Role of Decorin in Cell Response to BMP-2. Journal Of Cellular Physiology. 2006;206(1):58-67.

50
The Low Density Lipoprotein Receptor-Related Protein Functions As An Endocytic Receptor For Decorin
Autor(es): Brandan E, Retamal C, Cabello-Verrugio C, Marzolo M
Año: 2006.281:31562-31571.
Ref: Brandan E, Retamal C, Cabello-Verrugio C, Marzolo M. The Low Density Lipoprotein Receptor-Related Protein Functions As An Endocytic Receptor for Decorin. Journal Of Biological Chemistry. 2006;281(42):31562-31571.

51
Sulfation Is Required For Bone Morphogenetic Protein 2-Dependent Id1 Induction
Autor(es): Osses N, Gutierrez J, Lopez T, Ventura F, Brandan E
Año: 2006.344:1207-1215.
Ref: Osses N, Gutiérrez J, López T, Ventura F, Brandan E. Sulfation Is Required for Bone Morphogenetic Protein 2-Dependent Id1 Induction. Biochemical And Biophysical Research Communications. 2006;344(4):1207-1215.

52
Biglycan Is A New Extracellular Component Of The Chordin-Bmp4 Signaling Pathway
Autor(es): Moreno M, Munoz R, Aroca F, Labarca M, Brandan E, Larrain J
Año: 2005.24:1397-1405.
Ref: Moreno M, Muñoz R, Aroca F, Labarca M, Brandan E, Larraín J. Biglycan Is a New Extracellular Component of the Chordin-Bmp4 Signaling Pathway. Embo Journal. 2005;24(7):1397-1405.

53
Transient Up-Regulation Of Biglycan During Skeletal Muscle Regeneration: Delayed Fiber Growth Along With Decorin Increase In Biglycan-Deficient Mice
Autor(es): Casar J, Mckechnie B, Fallon J, Young M, Brandan E
Año: 2004.268:358-371.
Ref: Casar J, Mckechnie B, Fallon J, Young M, Brandan E. Transient Up-Regulation of Biglycan During Skeletal Muscle Regeneration: Delayed Fiber Growth Along With Decorin Increase in Biglycan-Deficient Mice. Developmental Biology. 2004;268(2):358-371.

54
Caenorhabditis Elegans Syndecan (Sdn-1) Is Required For Normal Egg Laying And Associates With The Nervous System And The Vulva
Autor(es): Minniti A, Labarca M, Hurtado C, Brandan E
Año: 2004.117:5179-5190.
Ref: Minniti A, Labarca M, Hurtado C, Brandan E. Caenorhabditis Elegans Syndecan (Sdn-1) Is Required for Normal Egg Laying and Associates With the Nervous System and the Vulva. Journal Of Cell Science. 2004;117(21):5179-5190.

55
Dermatan Sulfate Exerts An Enhanced Growth Factor Response On Skeletal Muscle Satellite Cell Proliferation And Migration
Autor(es): Villena J, Brandan E
Año: 2004.198:169-178.
Ref: Villena J, Brandan E. Dermatan Sulfate Exerts An Enhanced Growth Factor Response on Skeletal Muscle Satellite Cell Proliferation and Migration. Journal Of Cellular Physiology. 2004;198(2):169-178.

56
Structural And Functional Organization Of Synaptic Acetylcholinesterase
Autor(es): Aldunate R, Casar J, Brandan E, Inestrosa N
Año: 2004.47:96-104.
Ref: Aldunate R, Casar J, Brandan E, Inestrosa N. Structural and Functional Organization of Synaptic Acetylcholinesterase. Brain Research Reviews. 2004;47(1-3):96-104.

57
The Formation Of Skeletal Muscle Myotubes Requires Functional Membrane Receptors Activated By Extracellular Atp
Autor(es): Araya R, Riquelme M, Brandan E, Saez J
Año: 2004.47:174-188.
Ref: Araya R, Riquelme M, Brandan E, Sáez J. The Formation of Skeletal Muscle Myotubes Requires Functional Membrane Receptors Activated by Extracellular Atp. Brain Research Reviews. 2004;47(1-3):174-188.

58
Heparan Sulfate Proteoglycans Are Incresed During Skeletal Muscle Regeneration: Requirement Of Syndecan-3 For Successful Fiber Formation
Autor(es): Casar J, Cabello-Verrugio C, Olguin H, Aldunate R, Inestrosa N, Brandan E
Año: 2004.117:73-84.
Ref: Casar J, Cabello-Verrugio C, Olguín H, Aldunate R, Inestrosa N, Brandan E. Heparan Sulfate Proteoglycans Are Incresed During Skeletal Muscle Regeneration: Requirement of Syndecan-3 for Successful Fiber Formation. Journal Of Cell Science. 2004;117(21):73-84.

59
Inhibition Of Myoblast Migration Via Decorin Expression Is Critical For Normal Skeletal Muscle Differerentiation
Autor(es): Olguin H, Santander C, Brandan E
Año: 2003.259:209-224.
Ref: Olguín H, Santander C, Brandan E. Inhibition of Myoblast Migration Via Decorin Expression Is Critical for Normal Skeletal Muscle Differerentiation. Developmental Biology. 2003;259(2):209-224.

60
Betaglycan Expression Is Transcriptionally Up-Regulated During Skeletal Muscle Differentiation
Autor(es): Lopez F, Riquelme C, Perez Y, Ponce M, Osses N, Esparza J, Gonzalez G, Cabello C, Mendoza V, Troncoso V, Brandan E
Año: 2003.278:382-390.
Ref: López F, Riquelme C, Pérez Y, Ponce M, Osses N, Esparza J, González G, Cabello C, Mendoza V, Troncoso V, Brandan E. Betaglycan Expression Is Transcriptionally Up-Regulated During Skeletal Muscle Differentiation. Journal Of Biological Chemistry. 2003;278(1):382-390.

61
Extracellular Matrix Histone H1 Binds To Perlecan, Is Present In Regenerating Skeletal Muscle And Stimulates Myoblast Proliferation
Autor(es): Henriquez Jp, Casar Jc, Fuentealba L, Carey D, Brandan E
Año: 2002.115:2041-2051.
Ref: Henriquez JP, Casar JC, Fuentealba L, Carey D, Brandan E. Extracellular Matrix Histone H1 Binds to Perlecan, Is Present in Regenerating Skeletal Muscle and Stimulates Myoblast Proliferation. Journal Of Cell Science. 2002;115:2041-2051.

62
Ecm Is Required For Skeletal Muscle Differentiation Independently Of Muscle Regulatory Factor Expression
Autor(es): Osses N, Brandan E
Año: 2002.282:383-394.
Ref: Osses N, Brandan E. Ecm Is Required for Skeletal Muscle Differentiation Independently of Muscle Regulatory Factor Expression. American Journal Of Physiology-Cell Physiology. 2002;282(2):383-394.

63
Augmented Synthesis And Differential Localization Of Heparan Sulfate Proteoglycans In Duchenne Muscular Dystrophy
Autor(es): Alvarez K, Fadic R, Brandan E
Año: 2002.85:703-713.
Ref: Álvarez K, Fadic R, Brandan E. Augmented Synthesis and Differential Localization of Heparan Sulfate Proteoglycans in Duchenne Muscular Dystrophy. Journal Of Cellular Biochemistry. 2002;85(4):703-713.

64
Expression And Localization Of Proteoglycans Dyring Limb Myogenic Activation
Autor(es): Olguin H, Brandan E
Año: 2001.221:106-115.
Ref: Olguín H, Brandan E. Expression and Localization of Proteoglycans Dyring Limb Myogenic Activation. Developmental Dynamics. 2001;221(1):106-115.

65
Antisense Inhibition Of Decorin Expression In Myoblasts Decreases Cell Responsiveness To Transforming Growth Factor B And Accelerates Skeletal Muscle Defferentiation
Autor(es): Riquelme C, Larrain J, Schonherr E, Henriquez J, Kresse H, Brandan E
Año: 2001.276:3589-3596.
Ref: Riquelme C, Larraín J, Schonherr E, Henríquez J, Kresse H, Brandan E. Antisense Inhibition of Decorin Expression in Myoblasts Decreases Cell Responsiveness to Transforming Growth Factor B and Accelerates Skeletal Muscle Defferentiation. Journal Of Biological Chemistry. 2001;276(5):3589-3596.

66
Synthesis Of Proteoglycans Is Augmented In Dystrophic Mds Mause Skeletal Muscle
Autor(es): Caceres S, Cuellar C, Casar J, Garrido J, Schefer L, Kresse H, Brandan E
Año: 2000.79:173-181.
Ref: Cáceres S, Cuellar C, Casar J, Garrido J, Schefer L, Kresse H, Brandan E. Synthesis of Proteoglycans Is Augmented in Dystrophic Mds Mause Skeletal Muscle. European Journal Of Cell Biology. 2000;79(3):173-181.

67
Antisense Inhibition Of Syndecan-3 Expression During Skeletal Muscle Differentiation Accelerates Myogenesis Through A Basic Fibroblast Growth Factor-Dependent Mechanism
Autor(es): Fuentealba L, Carey D, Brandan E
Año: 1999.274:37876-37884.
Ref: Fuentealba L, Carey D, Brandan E. Antisense Inhibition of Syndecan-3 Expression During Skeletal Muscle Differentiation Accelerates Myogenesis Through a Basic Fibroblast Growth Factor-Dependent Mechanism. Journal Of Biological Chemistry. 1999;274(53):37876-37884.

68
Interaction Of Skeletal Muscle Cells With Collagen Type Iv Is Mediated By Perlecan Associated With The Cell Surface
Autor(es): Villar M, Hassell J, Brandan E
Año: 1999.75:665-674.
Ref: Villar M, Hassell J, Brandan E. Interaction of Skeletal Muscle Cells With Collagen Type IV Is Mediated by Perlecan Associated With the Cell Surface. Journal Of Cellular Biochemistry. 1999;75(4):665-674.

69
Decorin Core Protein Fragment Leu155-Val260 Interacts With Tgf-B But Does Not Compete For Decorin Binding To Type I Collagen
Autor(es): Schonherr E, Broszat M, Brandan E, Bruckner P, Kresse H
Año: 1998.355:241-248.
Ref: Schonherr E, Broszat M, Brandan E, Bruckner P, Kresse H. Decorin Core Protein Fragment Leu155-Val260 Interacts With Tgf-B But Does Not Compete for Decorin Binding to Type I Collagen. Archives Of Biochemistry And Biophysics. 1998;355(2):241-248.

70
Heparan Sulfate Proteoglycans During Terminal Skeletal Muscle Cell Differentiation: Possible Functions And Regulation Of Their Expression
Autor(es): Brandan E, Larrain J
Año: 1998.8:107-114.
Ref: Brandan E, Larraín J. Heparan Sulfate Proteoglycans During Terminal Skeletal Muscle Cell Differentiation: Possible Functions and Regulation of Their Expression. Basic And Applied Myology. 1998;8(2):107-114.

71
Syndecan-1 Expression Inhibits Myoblast Differentiation Through A Basic Fibroblast Growth Factor-Dependent Mechanism
Autor(es): Larrain J, Carey D, Brandan E
Año: 1998.273:32288-32296.
Ref: Larraín J, Carey D, Brandan E. Syndecan-1 Expression Inhibits Myoblast Differentiation Through a Basic Fibroblast Growth Factor-Dependent Mechanism. Journal Of Biological Chemistry. 1998;273(48):32288-32296.

72
Syndecan-1 Expression Is Down-Regulated During Myoblast Terminal Differentiation
Autor(es): Larrain J, Cizmeci-Smith G, Troncoso V, Stachl R, Carey D, Brandan E
Año: 1997.272:18418-18424.
Ref: Larraín J, Cizmeci-Smith G, Troncoso V, Stachl R, Carey D, Brandan E. Syndecan-1 Expression Is Down-Regulated During Myoblast Terminal Differentiation. Journal Of Biological Chemistry. 1997;272(29):18418-18424.

73
Expression Of Perlecan, A Proteologlycan That Binds Myogenic Inhibitory Basic Fibroblast Growth Factor, Is Down Regulated During Skeletal Muscle Differentation
Autor(es): Larrain J, Alvarez J, Hassell J, Brandan E
Año: 1997.234:405-412.
Ref: Larraín J, Álvarez J, Hassell J, Brandan E. Expression of Perlecan, a Proteologlycan That Binds Myogenic Inhibitory Basic Fibroblast Growth Factor, Is Down Regulated During Skeletal Muscle Differentation. Experimental Cell Research. 1997;234(2):405-412.

74
Interaction Between Alzheimer's Disease Ba4 Precursor Protein (App) And The Extracellular Matrix: Evidence For The Participation Of Heparan Sulfate Proteoglycans
Autor(es): Caceres J, Brandan E
Año: 1997.65:145-158.
Ref: Cáceres J, Brandan E. Interaction Between Alzheimer's Disease Ba4 Precursor Protein (App) and the Extracellular Matrix: Evidence for the Participation of Heparan Sulfate Proteoglycans. Journal Of Cellular Biochemistry. 1997;65(2):145-158.

75
Ethodin: Pharmacological Evidence Of The Interaction Between Smooth Muscle And Mast Cells In The Myometrium
Autor(es): Rudolph Mi, Garcia Ma, Sepulveda M, Brandan E, Reinicke K, Nicovani S, Villan L
Año: 1997.282:256-261.
Ref: Rudolph MI, García MA, Sepúlveda M, Brandan E, Reinicke K, Nicovani S, Villan L. Ethodin: Pharmacological Evidence of the Interaction Between Smooth Muscle and Mast Cells in the Myometrium. Journal Of Pharmacology And Experimental Therapeutics. 1997;282(1):256-261.

76
Extracellular Matrix Is Required For Skeletal Muscle Differentiation But Not Myogenin Expression
Autor(es): Melo F, Carey D, Brandan E
Año: 1996.62:227-239.
Ref: Melo F, Carey D, Brandan E. Extracellular Matrix Is Required for Skeletal Muscle Differentiation But Not Myogenin Expression. Journal Of Cellular Biochemistry. 1996;62(2):227-239.

77
Significantly Reduced Expression Of The Proteoglycan Decorin In Alzheimer's Disease Fibrolblats
Autor(es): Brandan E, Melo F, Garcia M, Contreras M
Año: 1996.49:M351-M356.
Ref: Brandan E, Melo F, García M, Contreras M. Significantly Reduced Expression of the Proteoglycan Decorin in Alzheimer's Disease Fibrolblats. Journal Of Clinical Pathology-Clinical Molecular Pathology Edition. 1996;49(6):M351-M356.

78
Synthesis And Processing Of Glypican During Differentiation Of Skeletal Muscle Cells
Autor(es): Brandan E, Carey D, Larrain J, Melo F, Campos A
Año: 1996.71:170-176.
Ref: Brandan E, Carey D, Larraín J, Melo F, Campos A. Synthesis and Processing of Glypican During Differentiation of Skeletal Muscle Cells. European Journal Of Cell Biology. 1996;71(2):170-176.

79
Behavioral Responses Of Concholepas Concholepas (Bruguiere, 1789) Larvae To Natural And Artificial Settlement Cues And Microbial Films
Autor(es): Rodriguez S, Riquelme C, Campos E, Chavez P, Brandan E, Inestrosa N
Año: 1995.189:272-279.
Ref: Rodríguez S, Riquelme C, Campos E, Chávez P, Brandan E, Inestrosa N. Behavioral Responses of Concholepas Concholepas (Bruguiere, 1789) Larvae to Natural and Artificial Settlement Cues and Microbial Films. Biological Bulletin. 1995;189(3):272-279.

80
Differentiation Of Oxyntic Cells And Cell-Matrix Interactions During Avian Gastric Gland Morphogenesis
Autor(es): Koenig C, Dabike M, Nunez R, Munizaga A, Brandan E, Garrido J
Año: 1994.:177-192.
Ref: Koenig C, Dabike M, Núñez R, Munizaga A, Brandan E, Garrido J. Differentiation of Oxyntic Cells and Cell-Matrix Interactions During Avian Gastric Gland Morphogenesis. Biological Research. 1994;(27):177-192.

81
Proteoglycans In Skeletal Muscle
Autor(es): Brandan E
Año: 1994.27:2109-2116.
Ref: Brandan E. Proteoglycans in Skeletal Muscle. Brazilian Journal Of Medical And Biological Research. 1994;27:2109-2116.

82
Isolation And Partial Characterization Of Cholesterol Pronucleating Hydrophobic Glycoproteins Associated To Native Biliary Vesicles
Autor(es): Miquel J, Nunez L, Rigotti A, Altermatt F, Brandan E, Nervi F, Amigo L
Año: 1993.318:45-49.
Ref: Miquel J, Nuñez L, Rigotti A, Altermatt F, Brandan E, Nervi F, Amigo L. Isolation and Partial Characterization of Cholesterol Pronucleating Hydrophobic Glycoproteins Associated to Native Biliary Vesicles. Febs Letters. 1993;318(1):45-49.

83
Effect Of Salt Concentration On The Synthesis Of Sulfated Macromolecules In The Brine Shrimp (Artemia Franciscana)
Autor(es): Brandan E, Urrea R, Gajardo G
Año: 1993.105A:519-523.
Ref: Brandan E, Urrea R, Gajardo G. Effect of Salt Concentration on the Synthesis of Sulfated Macromolecules in the Brine Shrimp (Artemia Franciscana). Comparative Biochemistry And Physiology A-Physiology. 1993;105A(3):519-523.

84
A Lipid- Anchoret Heparan Sulfate Proteoglycan Is Present In The Suface Of Differentiated Skeletal Muscle Cells. Isolation And Biochemical Characterization
Autor(es): Campos A, Nunez R, Konig C, Carey D, Brandan E
Año: 1993.216:587-595.
Ref: Campos A, Nuñez R, Konig C, Carey D, Brandan E. A Lipid- Anchoret Heparan Sulfate Proteoglycan Is Present in the Suface of Differentiated Skeletal Muscle Cells. Isolation and Biochemical Characterization. European Journal Of Biochemistry. 1993;216(2):587-595.

85
Decorin Is Specifically Solubilized By Heparin From The Extracellular Matrix Of Rat Skeletal Muscles
Autor(es): Brandan E, Melo F
Año: 1993.319:249-252.
Ref: Brandan E, Melo F. Decorin Is Specifically Solubilized by Heparin From the Extracellular Matrix of Rat Skeletal Muscles. Febs Letters. 1993;319(3):249-252.

86
Extracellular Matrix Components And Amyloid In Neuritic Plaques Of The Alzheimer`s Disease
Autor(es): Brandan E, Inestrosa N
Año: 1993.24:1063-1068.
Ref: Brandan E, Inestrosa N. Extracellular Matrix Components and Amyloid in Neuritic Plaques of the Alzheimer`S Disease. General Pharmacology. 1993;24(5):1063-1068.

87
Sulfation Is Required For Mobility Of Veliger Larvae Of Concholepas Concholepas...(Mollusca; Gastropoda; Muricidae)
Autor(es): Brandan E, Gonzalez M, Inestrosa N, Urrea R
Año: 1992.261:365-372.
Ref: Brandan E, González M, Inestrosa N, Urrea R. Sulfation Is Required for Mobility of Veliger Larvae of Concholepas Concholepas...(Mollusca; Gastropoda; Muricidae). Journal Of Experimental Zoology. 1992;261(4):365-372.

88
Isolation And Purification Of Human Biliary Vesicles With Potent Cholesterol Nucleation-Promoting Activity
Autor(es): Brandan E, Miquel Jf, Nervi F, Rigotti A, Rojas E
Año: 1992.82:175-180.
Ref: Brandan E, Miquel JF, Nervi F, Rigotti A, Rojas E. Isolation and Purification of Human Biliary Vesicles With Potent Cholesterol Nucleation-Promoting Activity. Clinical Science. 1992;82:175-180.

89
Decorin, A Chondroitin/dermatan Sulfate Proteoglycan Is Under Neural Control In Rat Skeletal Muscle
Autor(es): Andrade W, Brandan E, Fuentes M
Año: 1992.32:51-59.
Ref: Andrade W, Brandan E, Fuentes M. Decorin, a Chondroitin/Dermatan Sulfate Proteoglycan Is Under Neural Control in Rat Skeletal Muscle. Journal Of Neuroscience Research. 1992;32:51-59.

90
Axonal Sprouting Induced In The Sciatic Nerve By The Amyloid Precursor Protein (App) And Other Antiproteases
Autor(es): Alvarez J, Brandan E, Colby E, Esch F, Inestrosa N, Llanos D, Moreno R
Año: 1992.144:130-134.
Ref: Álvarez J, Brandan E, Colby E, Esch F, Inestrosa N, Llanos D, Moreno R. Axonal Sprouting Induced in the Sciatic Nerve by the Amyloid Precursor Protein (App) and Other Antiproteases. Neuroscience Letters. 1992;144:130-134.

91
Isolation Of Proteoglycans Synthesized By Rat Heart: Evidence For The Presence Of Several Distinct Forms
Autor(es): Gonzalez R, Urrea R, Gonzalez-Plaza M, Inestrosa N, Brandan E
Año: 1992.23:249-255.
Ref: González R, Urrea R, Gonzalez-Plaza M, Inestrosa N, Brandan E. Isolation of Proteoglycans Synthesized by Rat Heart: Evidence for the Presence of Several Distinct Forms. General Pharmacology-The Vascular System. 1992;23(2):249-255.

92
A High Molecular Weight Proteoglycan Is Differentially Expressed During Development Of Mollusc Concholepas Concholepas
Autor(es): Brandan E, Gonzalez E, Inestrosa N, Tremblay C, Urrea R
Año: 1992.264:1-1.
Ref: Brandan E, González E, Inestrosa N, Tremblay C, Urrea R. A High Molecular Weight Proteoglycan Is Differentially Expressed During Development of Mollusc Concholepas Concholepas. Journal Of Experimental Zoology. 1992;264(1):1-1.

93
The Protepolycan Decorin Is Synthesized And Secreted By Differentiated Myotybes
Autor(es): Andrade W, Brandan E, Fuentes M
Año: 1991.55:209-216.
Ref: Andrade W, Brandan E, Fuentes M. The Protepolycan Decorin Is Synthesized and Secreted by Differentiated Myotybes. European Journal Of Cell Biology. 1991;55(2):209-216.

94
Isolation And Characterization Of Rat Skeletal Muscle Proteoglycan Decorin And Comparison With The Human Fibroblast Decorin
Autor(es): Andrade W, Brandan E
Año: 1991.100:565-570.
Ref: Andrade W, Brandan E. Isolation and Characterization of Rat Skeletal Muscle Proteoglycan Decorin and Comparison With the Human Fibroblast Decorin. Comparative Biochemistry And Physiology B-Biochemistry & Molecular Biology. 1991;100(3):565-570.

95
Aspectos Biotecnológicos En Larvas De Loco
Autor(es): Araneda R, Brandan E, Campos E, Gonzalez M, Gonzalez-Plaza R, Inestrosa N, Labarca R, Perelman A, Sanchez J
Año: 1990.23:179-186.
Ref: Araneda R, Brandan E, Campos E, González M, González-Plaza R, Inestrosa N, Labarca R, Perelman A, Sánchez J. Aspectos Biotecnológicos en Larvas de Loco. Archivos De Biologia Y Medicina Experimental. 1990;23:179-186.

96
Motor Nerve Regulates Muscle Extracellular Matrix Proteoglycan Expression
Autor(es): Brandan E, Fadic R, Inestrosa N
Año: 1990.10:3516-3523.
Ref: Brandan E, Fadic R, Inestrosa N. Motor Nerve Regulates Muscle Extracellular Matrix Proteoglycan Expression. Journal Of Neuroscience. 1990;10(11):3516-3523.

97
Differential Association And Distribution Of Acetyl-And Butyrylcholinesterases Within Rat Liver Subcellular Organelles
Autor(es): Abeijon C, Brandan E, Hirschberg C, Inestrosa N, Perelman A
Año: 1990.265:214-220.
Ref: Abeijon C, Brandan E, Hirschberg C, Inestrosa N, Perelman A. Differential Association and Distribution of Acetyl-And Butyrylcholinesterases Within Rat Liver Subcellular Organelles. Journal Of Biological Chemistry. 1990;265(1):214-220.

98
Neurotransmitter-Related Enzyme Acetylcholinesterase In Juveniles Of Concholepas Concholepas (Mollusca; Gastropoda; Muricidae)
Autor(es): Brandan E, Castilla Jc, Fuentes M, Gonzalez M, Gonzalez-Plaza R, Inestrosa N, Labarca R, Perelman A
Año: 1990.255:1-8.
Ref: Brandan E, Castilla JC, Fuentes M, González M, González-Plaza R, Inestrosa N, Labarca R, Perelman A. Neurotransmitter-Related Enzyme Acetylcholinesterase in Juveniles of Concholepas Concholepas (Mollusca; Gastropoda; Muricidae). Journal Of Experimental Zoology. 1990;255:1-8.

99
Increase Of Macromolecules Synthesis After Hatching Of C. Concholepas Veliger Larvae: Effect Of Sulfate In The Synthesis Of Proteoglycans
Autor(es): Brandan E, Gonzalez M, Gonzalez-Plaza R, Inestrosa N
Año: 1990.96:613-619.
Ref: Brandan E, González M, González-Plaza R, Inestrosa N. Increase of Macromolecules Synthesis After Hatching of C. Concholepas Veliger Larvae: Effect of Sulfate in the Synthesis of Proteoglycans. Comparative Biochemistry And Physiology B-Biochemistry & Molecular Biology. 1990;96(3):613-619.

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