UC

FISIOLOGÍA

ITURRIAGA AGUERA,RODRIGO MANUEL

Rodrigo Manuel Iturriaga Aguera Rodrigo Manuel Iturriaga Aguera

Laboratorio:
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Profesor Titular

Laboratorio de Neurobiología

FISIOLOGÍA,
Facultad de Ciencias Biológicas,
Pontificia Universidad Católica de Chile, Alameda 340, Santiago

Antecedentes Académicos

Posdoctorado, University of Pennsylvania (1992).
Doctor, Pontificia Universidad Católica de Chile (1988).
Licenciado, Universidad de Concepción (1982).

Postdoctorado:

Fisiología. Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, USA, (1989-1992)

Especialización:

Neurobiología de quimiorreceptores arteriales y fisiología sensorial.

Premios y Distinciones

  • Premio de reconocimiento a la Excelencia Académica, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile (2009).
  • Mejor docente, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile (2007).

Actividades de Docencia

Pregado
  • 2019 MED214A-1, Bases Y Mecanismos De La Enfermedad I.
  • 2018 BIO299E-1, Fisiologia.
  • 2018 BIO262M-1, Neurofisiología.
Postgrado
  • 2019 BIO408A-1, Fisiologia Sensorial.

Líneas de Investigación

Los cuerpos carotídeos (CC) son los quimiorreceptores más importantes que sensan los niveles arteriales de PO2, PCO2 and pH. La hipoxia, hipercapnia y la acidosis aumentan la frecuencia de descarga de potenciales de acción en el nervio carotideo e inician los ajustes ventilatorios y cardiovasculares. Los CB contribuyen a la regulación de los gases respiratorios y tienen un papel predominante en el desarrollo de las respuestas ventilatorias en el recién nacido. Los CBs son importantes en la aclimatización y adaptación a la hipoxia de altura y en la reiniciación de la ventilación detenida en la apnea obstructiva del sueño. Los CBs han sido implicados en el desarrollo de la hipertensión y la muerte súbita del recién nacido. Existe acuerdo que la transducción del O2 ocurre en las células glómicas y que esta acoplada a la secreción -Ca2 -dependiente de al menos un transmisor, que aumenta la descarga en los terminales sensoriales. Las células glómicas contienen acetilcolina, catecolaminas, nucleótidos de adenosina y péptidos que podrían actuar como transmisores y/o moduladores quimiosensoriales. Pero, en el CB están presentes otras moléculas como el óxido nítrico que también participa en la quimiorrecepción. Existe un grado alto de co-localización de las enzimas que sintetizan) con péptidos en las células glómicas. Por lo tanto, es posible que las células glómicas en respuesta a los estímulos co-liberen más de un tipo de moléculas. Nosotros estamos interesados en determinar si acetilcolina y ATP son los transmisores excitatorios y determinar si DA y NO tienen un rol inhibitorio en el proceso quimiosensorial. Los resultados de estas investigaciones tienen implicaciones para entender no solo la fisiología quimiosensorial sino que son básicos para entender y prevenir el desarrollo de patologías cardiovasculares y respuestas ventilatorias anormales asociadas a los CBs.

 


Titulo: Uncovering The Role Of The Carotid Body Chemoreceptors In The Development Of The Hypertension During Chronic Intermittent Hypoxia: Is Oxidative Stress Necessary To Activate The Chemoreflex Pathway?
Año: 2015
Concurso e institución: Regular, CONICYT
Investigador principal: Iturriaga Aguera Rodrigo Manuel
Otros investigadores: Iturriaga Aguera Rodrigo Manuel, Valenzuela Bassi Rodrigo Andres, Del Rio Rodrigo
Fecha inicio: 01-03-2015
Fecha termino: 01-03-2019
Duración: 48 meses

Titulo: Modeling The Epigenetic Programming Of Vascular Dysfunction By Oxidative Stress In The Intrauterine Growth Restricted Fetus: Role Of Prenatal Antioxidants In Preventing Log-Term Vascular Dysfunction
Año: 2013
Concurso e institución: Regular, CONICYT
Investigador principal: Krause Leyton Bernardo Javier
Otros investigadores: Krause Leyton Bernardo Javier, Casanello Toledo Paola Cecilia, Farias Jofre Marcelo Enrique, Iturriaga Aguera Rodrigo Manuel, Herrera Videla Emilio
Fecha inicio: 01-03-2013
Fecha termino: 01-03-2017
Duración: 48 meses

Titulo: Nueva Formulación Farmacológica Para El Tratamiento Y La Prevención De La Hipertensión Arterial Y Disfunción Vascular: Respuesta Integrada A Una Patología Multifactorial
Año: 2013
Concurso e institución: , Otro
Investigador principal: Iturriaga Aguera Rodrigo Manuel
Otros investigadores: Iturriaga Aguera Rodrigo Manuel, Soto Arriaza Marco Antonio
Fecha inicio: 01-03-2013
Fecha termino: 01-03-2016
Duración: 36 meses

Titulo: Nueva Formulación Farmacológica Para El Tratamiento Y La Prevención De La Hipertensión Arterial Y Disfunción Vascular: Respuesta Integrada A Una Patología Multifactorial
Año: 2013
Concurso e institución: Investigación Y Desarrollo, CONICYT
Investigador principal: Iturriaga Aguera Rodrigo Manuel
Otros investigadores: Iturriaga Aguera Rodrigo Manuel, Casanello Toledo Paola Cecilia, Preite Marcelo Daniel, Manriquez Mujica Juan Manuel, Soto Arriaza Marco Antonio
Fecha inicio: 01-01-2013
Fecha termino: 01-01-2015
Duración: 24 meses

Titulo: Contribution Of The Carotid Body To The Hypertension Induced By Intermittent Hypoxia In A Rat Model Of Sleep Apnea: Role Of The Sympathetic System, Oxidative Stress And Pro-Inflammatory Cytokines
Año: 2010
Concurso e institución: Regular, CONICYT
Investigador principal: Iturriaga Aguera Rodrigo Manuel
Otros investigadores: Iturriaga Aguera Rodrigo Manuel, Alcayaga Urbina Julio Andres
Fecha inicio: 01-03-2010
Fecha termino: 01-03-2014
Duración: 48 meses

Titulo: Mecanismos Implicados En Las Alteraciones De La Funcion Vascular Inducidas Por Hipoxia Intermitente Crónica
Año: 2010
Concurso e institución: Especial, UC
Investigador principal: Iturriaga Aguera Rodrigo Manuel
Otros investigadores: Iturriaga Aguera Rodrigo Manuel, Casanello Toledo Paola Cecilia
Fecha inicio: 01-01-2010
Fecha termino: 31-12-2010
Duración: 12 meses

Titulo: Percepción De Alto Orden De Las Necesidades Del Cuerpo Y Emociones.
Año: 2009
Concurso e institución: , PBCT
Investigador principal: Torrealba Lopez Fernando
Otros investigadores: Torrealba Lopez Fernando, Iturriaga Aguera Rodrigo Manuel
Fecha inicio: 15-12-2009
Fecha termino: 15-12-2012
Duración: 36 meses

Titulo: Participation Of Petrosal Ganglion Neurons In The Increased Chemoreflex Sensibilty During Hypoxic Ventilatory Acclimatization
Año: 2009
Concurso e institución: Regular, CONICYT
Investigador principal: Alcayaga Urbina Julio
Otros investigadores: Alcayaga Urbina Julio, Iturriaga Aguera Rodrigo Manuel
Fecha inicio: 01-03-2009
Fecha termino: 01-03-2013
Duración: 48 meses

Titulo: Consecuencias Fisiopatologicas De La Hipoxia Intermitente Cronica Sobre La Quimiorrecepcion Carotidea Y La Regulacion Cardiorespiratoria
Año: 2007
Concurso e institución: Regular, CONICYT
Investigador principal: Iturriaga Aguera Rodrigo Manuel
Otros investigadores: Iturriaga Aguera Rodrigo Manuel, Alcayaga Urbina Julio, Varas Orozco Rodrigo
Fecha inicio: 01-03-2007
Fecha termino: 01-03-2010
Duración: 36 meses

Titulo: Caracterizacion Electrofisiologica Y Farmacologica De Los Receptores Involucrados En La Generacion De La Actividad Aferente Quimiosensorial Arterial En Neuronas Petrosas
Año: 2004
Concurso e institución: Regular, CONICYT
Investigador principal: Alcayaga Urbina Julio
Otros investigadores: Alcayaga Urbina Julio, Iturriaga Aguera Rodrigo Manuel
Fecha inicio: 01-03-2004
Fecha termino: 01-03-2008
Duración: 48 meses

Titulo: Aclimatización Ventilatoria A La Hipoxia Intermitente: Implicaciones Fisiológicas Y Patológicas
Año: 2003
Concurso e institución: Regular, CONICYT
Investigador principal: Iturriaga Aguera Rodrigo Manuel
Otros investigadores: Iturriaga Aguera Rodrigo Manuel, Alcayaga Urbina Julio
Fecha inicio: 01-03-2003
Fecha termino: 01-03-2007
Duración: 48 meses

Titulo: Transmisión Colinérgica En Quimiorreceptores Arteriales: Reconsideración
Año: 2001
Concurso e institución: Regular, CONICYT
Investigador principal: Zapata Ormeno Patricio
Otros investigadores: Zapata Ormeno Patricio, Iturriaga Aguera Rodrigo Manuel
Fecha inicio: 01-03-2001
Fecha termino: 01-03-2005
Duración: 48 meses


Publicaciones ISI

1
Acute Effects Of Systemic Erythropoietin Injections On Carotid Body Chemosensory Activity Following Hypoxic And Hypercapnic Stimulation
Autor(es): Rodrigo Iturriaga, Rodrigo Del Rio
Año: 2018.:95-102.10.1007/978-3-319-91137-3_12.
Ref: Rodrigo Iturriaga, Rodrigo Del Rio. Acute Effects of Systemic Erythropoietin Injections on Carotid Body Chemosensory Activity Following Hypoxic and Hypercapnic Stimulation. Advances In Experimental Medicine And Biology. 2018;(1071):95-102.

2
Cardiovascular Responses To Isometric Handgrip Exercise In Young Patients With Recurrent Vasovagal Syncope
Autor(es): Idiaquez J, Idiaquez Jf, Iturriaga R
Año: 2018.212:23-27.
Ref: Idiaquez J, Idiaquez JF, Iturriaga R. Cardiovascular responses to isometric handgrip exercise in young patients with recurrent vasovagal syncope. Autonomic Neuroscience-Basic & Clinical. 2018;212:23-27.

3
Carotid Body Type-I Cells Under Chronic Sustained Hypoxia: Focus On Metabolism And Membrane Excitability
Autor(es): Iturriaga Aguera Rodrigo Manue, Del Rio Troncoso Rodrigo Andre
Año: 2018.9:1-8.
Ref: Iturriaga Aguera Rodrigo Manue, Del Rio Troncoso Rodrigo Andre. Carotid body type-I cells under chronic sustained hypoxia: Focus on metabolism and membrane excitability. 2018;9(1282):1-8.

4
Proinflammatory Cytokines In The Nucleus Of The Solitary Tract Of Hypertensive Rats Exposed To Chronic Intermittent Hypoxia
Autor(es): Maria Maz Oyarce, Rodrigo Iturriaga
Año: 2018.:69-74.oi: 10.1007/978-3-319-91137-3_
Ref: Maria Maz Oyarce, Rodrigo Iturriaga. Proinflammatory Cytokines in the Nucleus of the Solitary Tract of Hypertensive Rats Exposed to Chronic Intermittent Hypoxia. Advances In Experimental Medicine And Biology. 2018;(1071):69-74.

5
Chronic Intermittent Hypoxia-Induced Vascular Dysfunction In Rats Is Reverted By N-Acetylcysteine Supplementation And Arginase Inhibition
Autor(es): Bernardo J. Krause, Paola Casanello, Ana C. Dias, Paulina Arias, Victoria Velarde, German A. Arenas, Marcelo D. Preite, Rodrigo Iturriaga
Año: 2018.:901-901.10.3389/fphys.2018.00901
Ref: Bernardo J. Krause, Paola Casanello, Ana C. Dias, Paulina Arias, Victoria Velarde, German A. Arenas, Marcelo D. Preite, Rodrigo Iturriaga. Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition. Frontiers In Physiology. 2018;(9):901-901.

6
Effects Of Vagotomy On Cardiovascular And Heart Rate Variability Alterations Following Chronic Normobaric Hypoxia In Adult Rabbits
Autor(es): Del Rio Troncoso Rodrigo Andre, Iturriaga Aguera Rodrigo Manue
Año: 2018.51.
Ref: Del Rio Troncoso Rodrigo Andre, Iturriaga Aguera Rodrigo Manue. Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits. 2018;51

7
Imbalance In Renal Vasoactive Enzymes Induced By Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases
Autor(es): Carlos P Vio, Rodrigo Iturriaga
Año: 2018.1791:1-14.10.3389/fphys.2018.01791
Ref: Carlos P Vio, Rodrigo Iturriaga. Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases. Frontiers In Physiology. 2018;1791(9):1-14.

8
Carotid Body Ablation: A New Target To Address Central Autonomic Dysfunction
Autor(es): Iturriaga R
Año: 2018.20:1-8.
Ref: Iturriaga R. Carotid Body Ablation: a New Target to Address Central Autonomic Dysfunction. Current Hypertension Reports. 2018;20(53):1-8.

9
Acute Effects Of Systemic Erythropoietin Injections On Carotid Body Chemosensory Activity Following Hypoxic And Hypercapnic Stimulation
Autor(es): David C. Andrade, Rodrigo Iturriaga, Florine Jeton, Julio Alcayaga, Nicolas Voituron, Rodrigo Del Rio, Rodrigo Del Rio
Año: 2018.1071:95-102.10.1007/978-3-319-91137-3_12
Ref: David C. Andrade, Rodrigo Iturriaga, Florine Jeton, Julio Alcayaga, Nicolas Voituron, Rodrigo Del Río, Rodrigo Del Río. Acute Effects of Systemic Erythropoietin Injections on Carotid Body Chemosensory Activity Following Hypoxic and Hypercapnic Stimulation. Advances In Experimental Medicine And Biology. 2018;1071(1):95-102.

10
Ventilatory And Autonomic Regulation In Sleep Apnea Syndrome: A Potential Protective Role For Erythropoietin?
Autor(es): Andrade Andrade David Cristoba, Iturriaga Aguera Rodrigo Manue, Del Rio Troncoso Rodrigo Andre
Año: 2018.9:1-8.
Ref: Andrade Andrade David Cristoba, Iturriaga Aguera Rodrigo Manue, Del Rio Troncoso Rodrigo Andre. Ventilatory and autonomic regulation in sleep apnea syndrome: A potential protective role for erythropoietin?. 2018;9(1440):1-8.

11
Topical Application Of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive In Rats.
Autor(es): Rodrigo Iturriaga, Rodrigo Del Rio
Año: 2018.:61-68.10.1007/978-3-319-91137-3_7.
Ref: Rodrigo Iturriaga, Rodrigo Del Rio. Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats.. Advances In Experimental Medicine And Biology. 2018;(1071):61-68.

12
Contribution Of Oxidative Stress And Inflammation To The Neurogenic Hypertension Induced By Intermittent Hypoxia
Autor(es): Oyarce Mp , Iturriaga R
Año: 2018.9:---.
Ref: Oyarce MP , Iturriaga R. Contribution of Oxidative Stress and Inflammation to the Neurogenic Hypertension Induced by Intermittent Hypoxia. Frontiers In Physiology. 2018;9(893):---.

13
Topical Application Of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive In Rats
Autor(es): David C. Andrade, Rodrigo Iturriaga, Camilo Toledo, Claudia M. Lucero, Hugo S. Diaz, Alexis Arce-Alvarez, Mauricio A. Retamal, Noah J. Marcus, Julio Alcayaga, Rodrigo Del Rio
Año: 2018.1071:61-68.doi.org/10.1007/978-3-319-9113
Ref: David C. Andrade, Rodrigo Iturriaga, Camilo Toledo, Claudia M. Lucero, Hugo S. Díaz, Alexis Arce-Alvarez, Mauricio A. Retamal, Noah J. Marcus, Julio Alcayaga, Rodrigo Del Río. Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats. Advances In Experimental Medicine And Biology. 2018;1071(1):61-68.

14
Role Of Carotid Body In Intermittent Hypoxia-Related Hypertension
Autor(es): Rodrigoiturriaga
Año: 2017.5:38-43.10.1007/s11906-017-0735-0
Ref: Rodrigo Iturriaga. Role of Carotid Body in Intermittent Hypoxia-Related Hypertension. Current Hypertension Reports. 2017;5(19):38-43.

15
Carotid Body Ablation Abrogates Hypertension And Autonomic Alterations Induced By Intermittent Hypoxia In Rats
Autor(es): Del Rio R, Andrade D, Lucero C , Arias P, Iturriaga R
Año: 2016.68:436-+-.
Ref: Del Rio R, Andrade D, Lucero C , Arias P, Iturriaga R. Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in Rats. Hypertension. 2016;68(2):436-+-.

16
Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation And Hypertension Are Critically Dependent On Peroxynitrite Formation
Autor(es): Moya Ea, Arias P, Varela C, Oyarce Mp, Del Rio R, Iturriaga R
Año: 2016.(2016):1-9.10.1155/2016/9802136
Ref: Moya EA, Arias P, Varela C, Oyarce MP, Del Rio R, Iturriaga R. Intermittent Hypoxia-Induced Carotid body chemosensory potentiation and hypertension are critically dependent on peroxynitrite formation. Oxidative Medicine and Cellular Longevity . 2016;(2016)(ID 9802136):1-9.

17
Carotid Body Chemoreceptors, Sympathetic Neural Activation, And Cardiometabolic Disease.
Autor(es): Iturriaga R, Del Rio R, Idiaquez J, Somers Vk
Año: 2016.13:1-12.10.1186/s40659-016-0073-8
Ref: Iturriaga R, Del Rio R, Idiaquez J, Somers VK. Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease.. Biological Research. 2016;13(49):1-12.

18
Inflammation And Oxidative Stress During Intermittent Hypoxia: The Impact On Chemoreception
Autor(es): Iturriaga R, Del Rio R, Moya
Año: 2015.100:149-155.10.1113/expphysiol.2014.079525
Ref: Iturriaga R, Del Rio R, Moya. Inflammation and oxidative stress during intermittent hypoxia: the impact on chemoreception. Experimental Physiology. 2015;100(2):149-155.

19
Arginase-Endothelial Nitric Oxide Synthase Imbalance Contributes To Endothelial Dysfunction During Chronic Intermittent Hypoxia
Autor(es): Krause B, Del Rio R, Moya E, Marquez-Gutierrez M, Casanello P, Iturriaga R
Año: 2015.33:515-524.
Ref: Krause B, Del Rio R, Moya E, Marquez-Gutierrez M, Casanello P, Iturriaga R. Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia. Journal Of Hypertension. 2015;33(3):515-524.

20
Carotid Body: A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease
Autor(es): Del Rio R, Iturriaga R, Schul
Año: 2015.6:---.10.3389/fphys.2015.00181
Ref: Del Rio R, Iturriaga R, Schul. Carotid body: a new target for rescuing neural control of cardiorespiratory balance in disease. Frontiers In Physiology. 2015;6(181):---.

21
Antioxidant And Anti Hyperglycemic Role Of Wine Grape Powder In Rats Fed With A High Fructose Diet
Autor(es): Hernandez R, Decap V, Leguina A, Caceres P, Perez D, Urquiaga I, Iturriaga R, Velarde V
Año: 2015.48:1-9.
Ref: Hernández R, Decap V, Leguina A, Cáceres P, Perez D, Urquiaga I, Iturriaga R, Velarde V. Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet. Biological Research. 2015;48(53):1-9.

22
Crucial Role Of The Carotid Body Chemoreceptors On The Development Of High Arterial Blood Pressure During Chronic Intermittent Hypoxia
Autor(es): Iturriaga R, Andrade Dc, Del
Año: 2015.860:255-260.
Ref: Iturriaga R, Andrade DC, Del. Crucial Role of the Carotid Body Chemoreceptors on the Development of High Arterial Blood Pressure During Chronic Intermittent Hypoxia. Advances In Experimental Medicine And Biology. 2015;860(-):255-260.

23
Crucial Role Of The Carotid Body Chemoreceptors On The Development Of High Arterial Blood Pressure During Chronic Intermittent Hypoxia
Autor(es): Rodrigo Iturriaga, David C Andrade, Rodrigo Del Rio
Año: 2015.860:255-260.
Ref: Rodrigo Iturriaga, David C Andrade, Rodrigo Del Rio. Crucial Role of the Carotid Body Chemoreceptors on the Development of High Arterial Blood Pressure During Chronic Intermittent Hypoxia. Advances In Experimental Medicine And Biology. 2015;860:255-260.

24
Inflammation And Oxidative Stress During Intermittent Hypoxia: The Impact On Chemoreception
Autor(es): Iturriaga R, Moya E, Del Rio R
Año: 2015.100:149-155.
Ref: Iturriaga R, Moya E, Del Rio R. Inflammation and oxidative stress during intermittent hypoxia: the impact on chemoreception. Experimental Physiology. 2015;100(2):149-155.

25
Carotid Body: A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease
Autor(es): Rodrigo Del Rio, Harold Schultz, Rodrigo Iturriaga
Año: 2014.:181-183.
Ref: Rodrigo Del Rio, Harold Schultz, Rodrigo Iturriaga. Carotid body: a new target for rescuing neural control of cardiorespiratory balance in disease. Frontiers In Physiology. 2014;(6):181-183.

26
Carotid Body Potentiation During Chronic Intermittent Hypoxia: Implication For Hypertension
Autor(es): Del Rio R, Moya E, Iturriaga R
Año: 2014.5:1-9.
Ref: Del Rio R, Moya E, Iturriaga R. Carotid body potentiation during chronic intermittent hypoxia: implication for hypertension. Frontiers In Physiology. 2014;5:1-9.

27
Enhanced Carotid Body Chemosensory Activity And The Cardiovascular Alterations Induced By Intermittent Hypoxia
Autor(es): Iturriaga R, Andrade D, Del Rio R
Año: 2014.5:1-9.
Ref: Iturriaga R, Andrade D, Del Rio R. Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia. Frontiers In Physiology. 2014;5:1-9.

28
Neurobehavioral And Autonomic Alterations In Adults With Obstructive Sleep Apnea
Autor(es): Idiaquez J, Santos I, Santin J, Del Rio R, Iturriaga R
Año: 2014.15:1319-1323.
Ref: Idiaquez J, Santos I, Santín J, Del Rio R, Iturriaga R. Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea. Sleep Medicine. 2014;15(11):1319-1323.

29
Chronic Hypoxia Induces The Activation Of The Wnt/beta-Catenin Signaling Pathway And Stimulates Hippocampal Neurogenesis In Wild-Type And Appswe-Ps1 Delta E9 Transgenic Mice In Vivo
Autor(es): Varela-Nallar L, Rojas-Abalos M, Abbott A, Moya E, Iturriaga R, Inestrosa N
Año: 2014.8:1-9.
Ref: Varela-Nallar L, Rojas-Abalos M, Abbott A, Moya E, Iturriaga R, Inestrosa N. Chronic hypoxia induces the activation of the Wnt/beta-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1 Delta E9 transgenic mice in vivo. Frontiers In Cellular Neuroscience. 2014;8:1-9.

30
Effect Of Insular Cortex Inactivation On Autonomic And Behavioral Responses To Acute Hypoxia In Conscious Rats
Autor(es): Casanova J, Contreras M, Moya E, Torrealba F, Iturriaga R
Año: 2013.253:60-67.
Ref: Casanova J, Contreras M, Moya E, Torrealba F, Iturriaga R. Effect of insular cortex inactivation on autonomic and behavioral responses to acute hypoxia in conscious rats. Behavioural Brain Research. 2013;253(15):60-67.

31
Inhibition Of Rat Carotid Body Glomus Cells Task-Like Channels By Acute Hypoxia Is Enhanced By Chronic Intermittent Hypoxia
Autor(es): Ortiz F, Del Rio R, Ebensperger G, Reyes V, Alcayaga J, Varas R, Iturriaga R
Año: 2013.185:600-607.
Ref: Ortiz F, Del Rio R, Ebensperger G, Reyes V, Alcayaga J, Varas R, Iturriaga R. Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia. Respiratory Physiology & Neurobiology. 2013;185(3):600-607.

32
Contribution Of Inflammation On Carotid Body Chemosensory Potentiation Induced By Intermittent Hypoxia
Autor(es): Del Rio R, Moya Ea, Iturriaga R
Año: 2012.:199-205.10.1007/978-94-007-4584-1_28.
Ref: Del Rio R, Moya EA, Iturriaga R. Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia. Advances In Experimental Medicine And Biology. 2012;(758):199-205.

33
Carotid Body Inflammation And Cardiorespiratory Alterations In Intermittent Hypoxia
Autor(es): Del Rio R , Moya E, Parga M, Madrid C , Iturriaga R
Año: 2012.39:1492-1500.
Ref: Del Rio R , Moya E, Parga M, Madrid C , Iturriaga R . Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. European Respiratory Journal. 2012;39(6):1492-1500.

34
Contribution Of Task-Like Potassium Channels To The Enhanced Rat Carotid Body Responsiveness To Hypoxia.
Autor(es): Ortiz Fc, Del Rio R, Varas R, Iturriaga R
Año: 2012.:365-371.10.1007/978-94-007-4584-1_49.
Ref: Ortiz FC, Del Rio R, Varas R, Iturriaga R. Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia.. Advances In Experimental Medicine And Biology. 2012;(758):365-371.

35
No Modulation Of Carotid Body Chemoreception In Health And Disease
Autor(es): Moya E, Alcayaga J, Iturriaga R
Año: 2012.184:158-164.
Ref: Moya E, Alcayaga J, Iturriaga R. NO modulation of carotid body chemoreception in health and disease. Respiratory Physiology & Neurobiology. 2012;184(2):158-164.

36
Ventilatory Responses To Peripheral Chemoexcitators: Effects Of Chronic Hypoxia
Autor(es): Alcayaga J, Del Rio R, Moya Ea, Freire M, Iturriaga R
Año: 2012.:307-313.10.1007/978-94-007-4584-1_42
Ref: Alcayaga J, Del Rio R, Moya EA, Freire M, Iturriaga R. Ventilatory Responses to Peripheral Chemoexcitators: Effects of Chronic Hypoxia. Advances In Experimental Medicine And Biology. 2012;(758):307-313.

37
Differential Expression Of Pro-Inflammatory Cytokines, Endothelin-1 And Nitric Oxide Synthases In The Rat Carotid Body Exposed To Intermittent Hypoxia
Autor(es): Del Rio R , Moya E, Iturriaga R
Año: 2011.1395:74-85.
Ref: Del Rio R , Moya E, Iturriaga R. Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia . Brain Research. 2011;1395:74-85.

38
Electrical Signal Measurements In Avocado Trees: A Potential Tool For Monitoring Physiological Responses To Soil Water Content?
Autor(es): Gil P, Gurovich L, Schaffer B, Alcayaga J, Iturriaga R
Año: 2011.889:371-378.
Ref: Gil P, Gurovich L, Schaffer B, Alcayaga J, Iturriaga R. Electrical signal measurements in avocado trees: A potential tool for monitoring physiological responses to soil water content?. Acta Horticulturae. 2011;889:371-378.

39
Chronic Intermittent Hypoxia-Induced Vascular Enlargement And Vegf Upregulation In The Rat Carotid Body Is Not Prevented By Antioxidant Treatment
Autor(es): Del Rio R, Munoz C, Arias P, Court Fa, Moya Ea, Iturriaga R
Año: 2011.301:L702-L711.
Ref: Del Rio R, Muñoz C, Arias P, Court FA, Moya EA, Iturriaga R. Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment. American Journal Of Physiology-Lung Cellular And Molecular Physiology. 2011;301:L702-L711.

40
Cardiorespiratory Alterations Induced By Intermittent Hypoxia In A Rat Model Of Sleep Apnea
Autor(es): Iturriaga R
Año: 2010.:271-274.
Ref: Iturriaga R. Cardiorespiratory alterations induced by intermittent hypoxia in a rat model of sleep apnea. Advances In Experimental Medicine And Biology. 2010;(669):271-274.

41
Carotid Body And Cardiorespiratory Alterations In Intermittent Hypoxia: The Oxidative Link
Autor(es): Del Rio R, Moya Ea, Iturriaga R
Año: 2010.36:143-150.
Ref: Del Río R, Moya EA, Iturriaga R. Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link. European Respiratory Journal. 2010;36(1):143-150.

42
Comparative Respiratory Strategies Of Subterranean And Fossorial Octodontid Rodents To Cope With Hypoxic And Hypercapnic Atmospheres
Autor(es): Tomasco Ih, Del Rio R, Iturriaga R, Bozinovic F
Año: 2010.180:877-884.
Ref: Tomasco IH, Del Río R, Iturriaga R, Bozinovic F. Comparative respiratory strategies of subterranean and fossorial octodontid rodents to cope with hypoxic and hypercapnic atmospheres. Journal Of Comparative Physiology B-Biochemical Systemic And Environmental Physiology. 2010;180(6):877-884.

43
Electrical Signaling, Stomatal Conductance, Aba And Ethylene Content In Avocado Trees In Response To Root Hypoxia
Autor(es): Gil, P. M, Gurovich, L., Schaffer, B, Garcia, N, Iturriaga, R
Año: 2009.4:100-108.
Ref: Gil, P. M, Gurovich, L., Schaffer, B, García, N, Iturriaga, R. Electrical signaling, stomatal conductance, ABA and Ethylene content in avocado trees in response to root hypoxia. Plant Signaling And Behavior. 2009;4(2):100-108.

44
Neurotransmitters In Carotid Body Function: The Case Of Dopamine - Invited Article
Autor(es): Iturriaga R, Alcayaga J, Gonzalez C
Año: 2009.648:137-143.
Ref: Iturriaga R, Alcayaga J, González C. Neurotransmitters in Carotid Body Function: The Case of Dopamine - Invited Article. Advances In Experimental Medicine And Biology. 2009;648:137-143.

45
Evidence For Histamine As A New Modulator Of Carotid Body Chemoreception
Autor(es): Del Rio R, Moya E, Alcayaga J, Iturriaga R
Año: 2009.1:177-184.
Ref: Del Río R, Moya E, Alcayaga J, Iturriaga R. Evidence for Histamine as a New Modulator of Carotid Body Chemoreception. Advances In Experimental Medicine And Biology. 2009;1:177-184.

46
Carotid Body Potentiation Induced By Intermittent Hypoxia: Implications For Cardiorespiratory Changes Induced By Sleep Apnoea
Autor(es): Iturriaga R, Moya Ea, Del Rio R
Año: 2009.36:1197-1204.
Ref: Iturriaga R, Moya EA, Del Río R. Carotid body potentiation induced by intermittent hypoxia: Implications for cardiorespiratory changes induced by sleep apnoea. Clinical And Experimental Pharmacology And Physiology. 2009;36(12):1197-1204.

47
Nitric Oxide Regulates Neurogenesis In Adult Olfactory Epithelium In Vitro
Autor(es): Sulz L, Astorga G, Bellette B, Iturriaga R, Mackay-Sim A, Bacigalupo J
Año: 2009.20:238-252.
Ref: Sulz L, Astorga G, Bellette B, Iturriaga R, Mackay-Sim A, Bacigalupo J. Nitric oxide regulates neurogenesis in adult olfactory epithelium in vitro. Nitric Oxide-Biology And Chemistry. 2009;20(4):238-252.

48
Cardioventilatory Acclimatization Induced By Chronic Intermittent Hypoxia
Autor(es): Iturriaga R, Rey S, Del Rio R, Moya Ea, Alcayaga J
Año: 2009.648:329-335.
Ref: Iturriaga R, Rey S, Del Río R, Moya EA, Alcayaga J. Cardioventilatory Acclimatization Induced by Chronic Intermittent Hypoxia. Advances In Experimental Medicine And Biology. 2009;648:329-335.

49
Neuroglobin In Aging Carotid Bodies
Autor(es): Verratti V, Di Giulio C, Bianchi G, Cacchio M, Petruccelli G, Di Giulio C, Artese L, Lahiri S, Iturriaga R
Año: 2009.648:191-195.
Ref: Verratti V, Di Giulio C, Bianchi G, Cacchio M, Petruccelli G, Di Giulio C, Artese L, Lahiri s, Iturriaga R. Neuroglobin in Aging Carotid Bodies. Advances In Experimental Medicine And Biology. 2009;648:191-195.

50
Sustained Hypoxia Enhances Task-Like Current Inhibition By Acute Hypoxia In Rat Carotid Body Type-I Cells
Autor(es): Ortiz F, Iturriaga R, Varas R
Año: 2009.648:83-88.
Ref: Ortíz F, Iturriaga R, Varas R. Sustained Hypoxia Enhances TASK-like Current Inhibition by Acute Hypoxia in Rat Carotid Body Type-I Cells. Advances In Experimental Medicine And Biology. 2009;648:83-88.

51
Dynamic Time-Varying Analysis Of Heart Rate And Blood Pressure Variability In Cats Exposed To Short-Term Chronic Intermittent Hypoxia
Autor(es): Rey S, Tarvainen M, Karjalainen P, Iturriaga R
Año: 2008.295:R28-R37.
Ref: Rey S, Tarvainen M, Karjalainen P, Iturriaga R. Dynamic time-varying analysis of heart rate and blood pressure variability in cats exposed to short-term chronic intermittent hypoxia. American Journal Of Physiology-Regulatory Integrative And Comparative Physiology. 2008;295(1):R28-R37.

52
Modulatory Effects Of Histamine On Cat Carotid Body Chemoreception
Autor(es): Del Rio R, Moya E, Koenig C, Fujiwara K, Alcayaga J, Iturriaga R
Año: 2008.3:401-410.
Ref: Del Río R, Moya E, Koenig C, Fujiwara K, Alcayaga J, Iturriaga R. Modulatory effects of histamine on cat carotid body chemoreception. Respiratory Physiology & Neurobiology. 2008;3(164):401-410.

53
Root To Leaf Electrical Signaling In Avocado In Response To Light And Soil Water Content
Autor(es): Gil P, Gurovich L, Schaffer B, Alcayaga J, Rey S, Iturriaga R
Año: 2008.165:1070-1078.
Ref: Gil P, Gurovich L, Schaffer B, Alcayaga J, Rey S, Iturriaga R. Root to leaf electrical signaling in avocado in response to light and soil water content. Journal Of Plant Physiology. 2008;165(10):1070-1078.

54
Contribution Of Endothelin-1 And Endothelin A And B Receptors To The Enhanced Carotid Body Chemosensory Responses Induced By Chronic Intermittent Hypoxia
Autor(es): Rey S, Del Rio R, Iturriaga R
Año: 2008.605:228-232.
Ref: Rey S, Del Río R, Iturriaga R. Contribution of endothelin-1 and endothelin A and B receptors to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia. Advances In Experimental Medicine And Biology. 2008;605:228-232.

55
Electrical And Pharmacological Properties Of Petrosal Ganglion Neurons That Innervate The Carotid Body
Autor(es): Iturriaga R, Varas R, Alcayaga J
Año: 2007.157:130-139.
Ref: Iturriaga R, Varas R, Alcayaga J. Electrical and pharmacological properties of petrosal ganglion neurons that innervate the carotid body. Respiratory Physiology & Neurobiology. 2007;157(1):130-139.

56
Expression And Immunolocalization Of Endothelin Peptides And Its Receptors, Eta And Etb, In The Carotid Body Exposed To Chronic Intermittent Hypoxia
Autor(es): Rey S, Corthorn J, Chacon C, Iturriaga R
Año: 2007.55:167-174.
Ref: Rey S, Corthorn J, Chacón C, Iturriaga R. Expression and immunolocalization of endothelin peptides and its receptors, ETA and ETB, in the carotid body exposed to chronic intermittent hypoxia. Journal Of Histochemistry & Cytochemistry. 2007;55(2):167-174.

57
Atp- And Ach-Induced Responses In Isolated Cat Petrosal Ganglion Neurons.
Autor(es): Alcayaga C, Varas R, Valdes V, Cerpa V, Arroyo J, Iturriaga R, Alcayaga J
Año: 2007.1:60-67.:10.1016/j.b
Ref: Alcayaga C, Varas R, Valdes V, Cerpa V, Arroyo J, Iturriaga R, Alcayaga J. ATP- and ACh-induced responses in isolated cat petrosal ganglion neurons.. Brain Research. 2007;1(1131):60-67.

58
Effects Of Intermittent Hypoxia On Cat Petrosal Ganglion Responses Induced By Acetylcholine, Adenosine 5 '-Triphosphate And Nacn
Autor(es): Iturriaga R, Alcayaga J
Año: 2007.1128:86-90.
Ref: Iturriaga R, Alcayaga J. Effects of intermittent hypoxia on cat petrosal ganglion responses induced by acetylcholine, adenosine 5 '-triphosphate and NaCN. Brain Research. 2007;1128(1):86-90.

59
Pathophysiology Of Obstructive Sleep Apnea-Associated Hypertension
Autor(es): Rey S, Valdes G, Iturriaga R
Año: 2007.135:1333-1342.
Ref: Rey S, Valdés G, Iturriaga R. Pathophysiology of obstructive sleep apnea-associated hypertension. Revista Medica De Chile. 2007;135(10):1333-1342.

60
Root To Leaf Electrical Signaling In Avocado In Response To Light And Soil Water Content.
Autor(es): Gil P, Gurovich L, Bruce S, Alcayaga J, Iturriaga R
Año: 2007.100:1-100.
Ref: Gil P, Gurovich L, Bruce S, Alcayaga J, Iturriaga R. Root to leaf electrical signaling in avocado in response to light and soil water content.. Journal Of Plant Physiology. 2007;100(100):1-100.

61
Neuroglobin, A New Oxygen Binding Protein Is Present In The Carotid Body And Increases After Chronic Intermittent Hypoxia
Autor(es): Di Giulio C, Bianchi G, Cacchio M, Artese L, Piccirilli M, Verratti V, Valerio R, Iturriaga R
Año: 2006.580:15-19.
Ref: Di Giulio C, Bianchi G, Cacchio M, Artese L, Piccirilli M, Verratti V, Valerio R, Iturriaga R. Neuroglobin, a new oxygen binding protein is present in the carotid body and increases after chronic intermittent hypoxia. Advances In Experimental Medicine And Biology. 2006;580(0):15-19.

62
Contribution Of Endothelin-1 To The Enhanced Carotid Body Chemosensory Responses Induced By Chronic Intermittent Hypoxia
Autor(es): Rey S, Del Rio R, Iturriaga R
Año: 2006.1086:152-159.
Ref: Rey S, Del Río R, Iturriaga R. Contribution of Endothelin-1 to the Enhanced Carotid Body Chemosensory Responses Induced by Chronic Intermittent Hypoxia. Brain Research. 2006;1086:152-159.

63
Electrophysiological Characterization Of Nicotinic Acetylcholine Receptors In Cat Petrosal Ganglion Neurons In Culture: Effects Of Cytisine And Its Bromo Derivatives
Autor(es): Varas R, Valdes V, Iturriaga-Vasquez P, Cassels B, Iturriaga R, Alcayaga J
Año: 2006.1072:72-78.
Ref: Varas R, Valdés V, Iturriaga-Vásquez P, Cassels B, Iturriaga R, Alcayaga J. Electrophysiological Characterization of Nicotinic Acetylcholine Receptors in Cat Petrosal Ganglion Neurons in Culture: Effects of Cytisine and Its Bromo Derivatives. Brain Research. 2006;1072(1):72-78.

64
Endothelins In The Cat Petrosal Ganglion And Carotid Body: Effects And Immunolocalization
Autor(es): Rey S, Del Rio R, Alcayaga J, Iturriaga R
Año: 2006.1069:154-158.
Ref: Rey S, Del Río R, Alcayaga J, Iturriaga R. Endothelins in the Cat Petrosal Ganglion and Carotid Body: Effects and Immunolocalization. Brain Research. 2006;1069(1):154-158.

65
Cardiovascular And Ventilatory Acclimatization Induced By Chronic Intermittent Hypoxia: A Role For The Carotid Body In The Pathophysiology Of Sleep Apnea
Autor(es): Iturriaga R, Rey S, Del Rio R
Año: 2005.38:335-340.
Ref: Iturriaga R, Rey S, Del Río R. Cardiovascular and Ventilatory Acclimatization Induced by Chronic Intermittent Hypoxia: a Role for the Carotid Body in the Pathophysiology of Sleep Apnea. Biological Research. 2005;38(4):335-340.

66
Neurotransmission In The Carotid Body: Transmitters And Modulators Between Glomus Cells And Petrosal Ganglion Nerve Terminals
Autor(es): Iturriaga R, Alcayaga J
Año: 2004.47:46-53.
Ref: Iturriaga R, Alcayaga J. Neurotransmission in the Carotid Body: Transmitters and Modulators Between Glomus Cells and Petrosal Ganglion Nerve Terminals. Brain Research Reviews. 2004;47(1-3):46-53.

67
Chronic Intermittent Hypoxia Enhances Cat Chemosensory And Ventilatory Responses To Hypoxia
Autor(es): Rey S, Del Rio R, Alcayaga J, Iturriaga R
Año: 2004.560:577-586.
Ref: Rey S, Del Río R, Alcayaga J, Iturriaga R. Chronic Intermittent Hypoxia Enhances Cat Chemosensory and Ventilatory Responses to Hypoxia. Journal Of Physiology-London. 2004;560(2):577-586.

68
Endothelins And Nitric Oxide: Vasoactive Modulators Of Carotid Body Chemoreception
Autor(es): Rey S, Iturriaga R
Año: 2004.1:465-473.
Ref: Rey S, Iturriaga R. Endothelins and Nitric Oxide: Vasoactive Modulators of Carotid Body Chemoreception. Current Neurovascular Research. 2004;1(5):465-473.

69
Carotid Chemosensory Neurons In The Petrosal Ganglia Are Excited By Ach And Atp
Autor(es): Varas R, Alcayaga J, Iturriaga R
Año: 2003.536:321-326.
Ref: Varas R, Alcayaga J, Iturriaga R. Carotid chemosensory neurons in the petrosal ganglia are excited by ACh and ATP. Advances In Experimental Medicine And Biology. 2003;536(0):321-326.

70
Catecholamine Release From Isolated Sensory Neurons Of Cat Petrosal Ganglia In Tissue Culture
Autor(es): Iturriaga R, Cerpa V, Zapata P, Alcayaga J
Año: 2003.984:104-110.
Ref: Iturriaga R, Cerpa V, Zapata P, Alcayaga J. Catecholamine Release From Isolated Sensory Neurons of Cat Petrosal Ganglia in Tissue Culture. Brain Research. 2003;984(1-2):104-110.

71
Ach And Atp Mediate Excitatory Transmission In Cat Carotid Identified Chemoreceptor Units In Vitro
Autor(es): Varas R, Alcayaga J, Iturriaga R
Año: 2003.988:154-163.
Ref: Varas R, Alcayaga J, Iturriaga R. ACh and ATP Mediate Excitatory Transmission in Cat Carotid Identified Chemoreceptor Units in Vitro. Brain Research. 2003;988(1-2):154-163.

72
Inhibitory Effects Of No On Carotid Body: Contribution Of Neural And Endothelial Nitric Oxide Synthase Isoforms
Autor(es): Valdes V, Mosqueira M, Rey S, Del Rio R, Iturriaga R
Año: 2003.284:L57-L68.
Ref: Valdés V, Mosqueira M, Rey S, Del Río R, Iturriaga R. Inhibitory Effects of No on Carotid Body: Contribution of Neural and Endothelial Nitric Oxide Synthase Isoforms. American Journal Of Physiology-Lung Cellular And Molecular Physiology. 2003;284(1):L57-L68.

73
Carotid Body Chemosensory Excitation Iduced By Nitric Oxide: Involvement Of Oxidative Metabolism
Autor(es): Mosqueira M, Iturriaga R
Año: 2002.131:175-187.
Ref: Mosqueira M, Iturriaga R. Carotid Body Chemosensory Excitation Iduced by Nitric Oxide: Involvement of Oxidative Metabolism. Respiratory Physiology & Neurobiology. 2002;131(3):175-187.

74
The Excitatory Effect Of Nitric Oxide On Carotid Body Chemoreception Is Blocked By Oligomycin
Autor(es): Iturriaga R, Mosqueira M
Año: 2001.499:55-60.
Ref: Iturriaga R, Mosqueira M. The excitatory effect of nitric oxide on carotid body chemoreception is blocked by oligomycin. Advances In Experimental Medicine And Biology. 2001;499(0):55-60.

75
Nitric Oxide And Carotid Body Chemoreception
Autor(es): Iturriaga R
Año: 2001.34:135-139.
Ref: Iturriaga R. Nitric Oxide and Carotid Body Chemoreception. Biological Research. 2001;34(2):135-139.

76
Effects Of Nitric Oxide Gas On Cat Carotid Body Chemosensory Response To Hypoxia
Autor(es): Iturriaga R, Mosqueira M, Villanueva S
Año: 2000.855:282-286.
Ref: Iturriaga R, Mosqueira M, Villanueva S. Effects of Nitric Oxide Gas on Cat Carotid Body Chemosensory Response to Hypoxia. Brain Research. 2000;855(2):282-286.

77
Dual Effects Of Nitric Oxide On Cat Carotid Body Chemoreception
Autor(es): Iturriaga R, Villanueva S, Mosqueira M
Año: 2000.89:1005-1012.
Ref: Iturriaga R, Villanueva S, Mosqueira M. Dual Effects of Nitric Oxide on Cat Carotid Body Chemoreception. Journal Of Applied Physiology. 2000;89(3):1005-1012.

78
Responses Of Petrosal Ganglion Neurons In Vitro To Hypoxic Stimuli And Putative Transmitters
Autor(es): Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P
Año: 2000.475:389-396.
Ref: Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P. Responses of petrosal ganglion neurons in vitro to hypoxic stimuli and putative transmitters. Advances In Experimental Medicine And Biology. 2000;475(0):389-396.

79
Interactions Between Acetylcholine And Dopamine In Chemoreception
Autor(es): Zapata P, Larrain C, Iturriaga R, Alcayaga J, Eyzaguirre C
Año: 2000.475:495-505.
Ref: Zapata P, Larrain C, Iturriaga R, Alcayaga J, Eyzaguirre C. Interactions between acetylcholine and dopamine in chemoreception. Advances In Experimental Medicine And Biology. 2000;475(0):495-505.

80
Adenosine Triphosphate-Induced Peripheral Nerve Discharges Generated From The Cat Petrosal Ganglion In Vitro
Autor(es): Alcayaga J, Cerpa V, Retamal M, Arroyo J, Iturriaga R, Zapata P
Año: 2000.282:185-188.
Ref: Alcayaga J, Cerpa V, Retamal M, Arroyo J, Iturriaga R, Zapata P. Adenosine Triphosphate-Induced Peripheral Nerve Discharges Generated From the Cat Petrosal Ganglion in Vitro. Neuroscience Letters. 2000;282(3):185-188.

81
Lack Of Correlation Between Cholinergic-Induced Changes In Chemosensory Activity And Dopamine Release From The Cat Carotid Body In Vitro
Autor(es): Iturriaga R, Alcayaga J, Zapata P
Año: 2000.868:380-385.
Ref: Iturriaga R, Alcayaga J, Zapata P. Lack of Correlation Between Cholinergic-Induced Changes in Chemosensory Activity and Dopamine Release From the Cat Carotid Body in Vitro. Brain Research. 2000;868(2):380-385.

82
Nitric Oxide Modulation Of Carotid Chemoreception
Autor(es): Iturriaga R, Villanueva S, Alcayaga J
Año: 2000.475:761-768.
Ref: Iturriaga R, Villanueva S, Alcayaga J. Nitric oxide modulation of carotid chemoreception. Advances In Experimental Medicine And Biology. 2000;475(0):761-768.

83
Responses To Hypoxia Of Petrosal Ganglia In Vitro
Autor(es): Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P
Año: 1999.845:28-34.
Ref: Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P. Responses to Hypoxia of Petrosal Ganglia in Vitro. Brain Research. 1999;845(1):28-34.

84
Dopamine Modulates Carotid Nerve Responses Induced By Acetylcholine On Cat Petrosal Ganglion In Vitro
Autor(es): Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P
Año: 1999.831:97-103.
Ref: Alcayaga J, Varas R, Arroyo J, Iturriaga R, Zapata P. Dopamine Modulates Carotid Nerve Responses Induced by Acetylcholine on Cat Petrosal Ganglion in Vitro. Brain Research. 1999;831(1-2):97-103.

85
Modulatory Effect Of Nitric Oxide On Acetylcholine-Induced Activation Of Cat Petrosal Ganglion Neurons In Vitro
Autor(es): Alcayaga J, Barrios M, Bustos F, Miranda G, Molina M, Iturriaga R
Año: 1999.825:194-198.
Ref: Alcayaga J, Barrios M, Bustos F, Miranda G, Molina M, Iturriaga R. Modulatory Effect of Nitric Oxide on Acetylcholine-Induced Activation of Cat Petrosal Ganglion Neurons in Vitro. Brain Research. 1999;825(1-2):194-198.

86
Anion Exchanger And Chloride Channel In Cat Carotid Body Chemotransfuction
Autor(es): Iturriaga R, Mokashi A, Lahiri S
Año: 1998.70:23-31.
Ref: Iturriaga R, Mokashi A, Lahiri S. Anion Exchanger and Chloride Channel in Cat Carotid Body Chemotransfuction. Journal Of The Autonomic Nervous System. 1998;70(1-2):23-31.

87
Sodium Nitroprusside Blicks The Cat Carotid Chemosensory Inhibition Induced By Dopamine, But Not That By Hyperoxia
Autor(es): Iturriaga R, Alcayaga J, Rey S
Año: 1998.799:26-34.
Ref: Iturriaga R, Alcayaga J, Rey S. Sodium Nitroprusside Blicks the Cat Carotid Chemosensory Inhibition Induced by Dopamine, But Not That by Hyperoxia. Brain Research. 1998;799(1):26-34.

88
Effects Of Co2-Hco3- On Catecholamine Efflux From Cat Carotid Body
Autor(es): Iturriaga R, Alcayaga J
Año: 1998.84:60-68.
Ref: Iturriaga R, Alcayaga J. Effects of CO2-HCO3- on catecholamine efflux from cat carotid body. Journal Of Applied Physiology. 1998;84(1):60-68.

89
Selective Activation Of Carotid Nerve Fibers By Acetylcholine Applied To The Cat Petrosal Ganglion In Vitro
Autor(es): Alcayaga J, Iturriaga R, Varas R, Arroyo J, Zapata P
Año: 1998.786:47-54.
Ref: Alcayaga J, Iturriaga R, Varas R, Arroyo J, Zapata P. Selective Activation of Carotid Nerve Fibers by Acetylcholine Applied to the Cat Petrosal Ganglion in Vitro. Brain Research. 1998;786(1-2):47-54.

90
Cat Carotid Body Chemosensory Responses To Non-Hypoxic Stimuli Are Inhibited By Sodium Nitroprusside In Situ And In Vitro
Autor(es): Alcayaga J, Iturriaga R, Ramirez J, Readi R, Quezada C, Salinas P
Año: 1997.767:384-387.
Ref: Alcayaga J, Iturriaga R, Ramírez J, Readi R, Quezada C, Salinas P. Cat Carotid Body Chemosensory Responses to Non-Hypoxic Stimuli Are Inhibited by Sodium Nitroprusside in Situ and in Vitro. Brain Research. 1997;767(2):384-387.

91
Time Structure, Temporal Correlation And Coherence Of Chemosensory Impulses Propagated Through Both Carotid Nerves In Cats
Autor(es): Alcayaga J, Iturriaga R, Zapata P
Año: 1997.30:125-133.
Ref: Alcayaga J, Iturriaga R, Zapata P. Time Structure, Temporal Correlation and Coherence of Chemosensory Impulses Propagated Through Both Carotid Nerves in Cats. Biological Research. 1997;30(3):125-133.

92
Dopamine Efflux From The Carotid Body During Hypoxic Stimulation
Autor(es): Zapata P, Iturriaga R, Alcayaga J
Año: 1996.410:261-266.
Ref: Zapata P, Iturriaga R, Alcayaga J. Dopamine Efflux From the Carotid Body During Hypoxic Stimulation. Advances In Experimental Medicine And Biology. 1996;410:261-266.

93
Domperidone As A Tool To Assess The Role Of Dopamine Within Carotid Body Chemoreception
Autor(es): Zapata P, Iturriaga R, Larrain C
Año: 1996.410:291-297.
Ref: Zapata P, Iturriaga R, Larrain C. Domperidone As a Tool to Assess the Role of Dopamine Within Carotid Body Chemoreception. Advances In Experimental Medicine And Biology. 1996;410:291-297.

94
Intracellular Acidosis Potentiates Carotid Chemoreceptor Responses To Hypoxia In The Absence Of Co2-Hco3-
Autor(es): Iturriaga R
Año: 1996.:211-216.
Ref: Iturriaga R. Intracellular Acidosis Potentiates Carotid Chemoreceptor Responses to Hypoxia in the Absence of Co2-Hco3-. Advances In Experimental Medicine And Biology. 1996;:211-216.

95
Acetate Enhances The Chemosensory Response To Hypoxia In The Cat Carotid Body In Vitro In The Absence Of Co2-Hco3-
Autor(es): Iturriaga R
Año: 1996.:237-243.
Ref: Iturriaga R. Acetate Enhances the Chemosensory Response to Hypoxia in the Cat Carotid Body in Vitro in the Absence of Co2-Hco3-. Biological Research. 1996;(29):237-243.

96
Coherence Of Chemosensory Discharges In Cats' Carotid Nerves
Autor(es): Alcayaga J, Iturriaga R, Zapata P
Año: 1996.410:349-356.
Ref: Alcayaga J, Iturriaga R, Zapata P. Coherence of Chemosensory Discharges in Cats' Carotid Nerves. Advances In Experimental Medicine And Biology. 1996;410:349-356.

97
Effects Of Dopaminergic Blockade Upon Carotid Chemosensory Activity And Its Hypoxia-Induced Excitation
Autor(es): Iturriaga R, Larrain C, Zapata P
Año: 1994.663:145-154.
Ref: Iturriaga R, Larrain C, Zapata P. Effects of Dopaminergic Blockade Upon Carotid Chemosensory Activity and Its Hypoxia-Induced Excitation. Brain Research. 1994;663:145-154.

98
Phrenic Nerve Activity During Artificial Ventilation At Different Body Temperatures And Its Relationships With Carotid Chemosensory Activity
Autor(es): Iturriaga R, Larrain C, Zapata P
Año: 1994.27:145-157.
Ref: Iturriaga R, Larrain C, Zapata P. Phrenic Nerve Activity During Artificial Ventilation At Different Body Temperatures and Its Relationships With Carotid Chemosensory Activity. Biological Research. 1994;27(2):145-157.

99
Carotid Body Chemoreception: The Importance Of Co2-Hco3 And Carbonic Anhydrase
Autor(es): Iturriaga R
Año: 1993.26:319-329.
Ref: Iturriaga R. Carotid Body Chemoreception: the Importance of Co2-Hco3 and Carbonic Anhydrase. Biological Research. 1993;26(3):319-329.



Libros y Capitulos de Libros


Contribution Of Autonomic Nervous System To The Hypertension Induced By Obstructive Sleep Apnea
Autor(es): Rodrigo Iturriaga, Juan Idiaquez
Año: 2014:137-152.
Ref: Rodrigo Iturriaga, Juan Idiaquez. Contribution of Autonomic Nervous System to the Hypertension Induced by Obstructive Sleep Apnea. In: Dr. Chris Idzikowski,editors. Sleep and its Disorders Affect Society. Croacia: INTECH; 2014. p. 137-152.

Oxidative Stress In The Carotid Body: Implications For The Cardioventilatory Alterations Induced By Obstructive Sleep Apnea
Autor(es): Rodrigo Iturriaga, Rodrigo Del Rio
Año: 2012:71-86.
Ref: Rodrigo Iturriaga, Rodrigo Del Rio. Oxidative stress in the carotid body: Implications for the Cardioventilatory Alterations Induced by Obstructive Sleep Apnea. In: LUSHCHAK VI, GOSPODARYOV DV,editors. Oxidative Stress and Diseases. Croacia: InTech. Open Access Publisher; 2012. p. 71-86.

Sistema Simptico E Hipertensin Arterial
Autor(es): Rey Sergio, Iturriaga Rodrigo
Año: 2008:85-96.
Ref: Rey Sergio, Iturriaga Rodrigo. Sistema simpático e hipertensión arterial. In: Carlos Saieh Carlos Zehnder,editors. Hipertension Arterial. Chile: Mediterraneo; 2008. p. 85-96.

Carotid Body Transmitters Actions On Rabbit Petrosal Ganglion In Vitro
Autor(es): Alcayaga J, Soto C, Vargas R, Ortiz J, Arroyo J, Iturriaga R
Año: 2006:331-337.
Ref: Alcayaga J, Soto C, Vargas R, Ortíz J, Arroyo J, Iturriaga R. Carotid Body Transmitters Actions on Rabbit Petrosal Ganglion in Vitro. In: Yoshiaki Hayashida, Contancio ,editors. The Arterial Chemoreceptors. Springer; 2006. p. 331-337.

Chronic Intermittent Hypoxia Enhances Carotid Body Chemosensory Reponses To Acute Hypoxia
Autor(es): Iturriaga R, Rey S, Alcayaga J
Año: 2006:227-232.
Ref: Iturriaga R, Rey S, Alcayaga J. Chronic Intermittent Hypoxia Enhances Carotid Body Chemosensory Reponses to Acute Hypoxia. In: Yoshiaki H., Constancio G., Hi,editors. The Arterial Chemoreceptors. Springer; 2006. p. 227-232.

Neuroglobin, A Putative Trasmiter In The Carotid Body, Increases After Chronic Hypoxia
Autor(es): Di Giulio C, Bianchi G, Cacchio M, Artese L, Piccirilli M, Verratti V, Valerio R, Iturriaga R
Año: 2006:15-19.
Ref: Di Giulio C, Bianchi G, Cacchio M, Artese L, Piccirilli M, Verratti V, Valerio R, Iturriaga R. Neuroglobin, a Putative Trasmiter in the Carotid Body, Increases After Chronic Hypoxia. In: Hayashida Y, Gonzalez C, Kondo,editors. The Arterial Chemoreceptors. Springer; 2006. p. 15-19.

Role Of Endothelin-1 On The Enhanced Carotid Body Activity Induces By Chronic Intermittent Hypoxia
Autor(es): Rey S, Del Rio R, Iturriaga R
Año: 2006:345-350.
Ref: Rey S, Del Río R, Iturriaga R. Role of Endothelin-1 on the Enhanced Carotid Body Activity Induces by Chronic Intermittent Hypoxia. In: Yoshiaki H.,Contancio G.,Hisat,editors. The Arterial Chemoreceptors. Springer; 2006. p. 345-350.

Contribution Of Neural And Endothelial Isoforms Of The Nitric Oxide Synthase To The Inhibitory Effects Of No On The Cat Carotid Body
Autor(es): Valdes V, Mosqueira M, Iturriaga R
Año: 2003:345-351.
Ref: Valdes V, Mosqueira M, Iturriaga R. Contribution of Neural and Endothelial Isoforms of the Nitric Oxide Synthase to the Inhibitory Effects of No on the Cat Carotid Body. In: J.Pequignot,C.Gonzalez,C.Nurse,editors. Chemoreception: From Cellular Signaling to Functional Plasticity. Kluwer Academic; 2003. p. 345-351.

Nitric Oxide And Carotid Body Chemoreception: Multiple Targets Sites
Autor(es): Iturriaga R, Alcayaga J
Año: 2003:409-420.
Ref: Iturriaga R, Alcayaga J. Nitric Oxide and Carotid Body Chemoreception: Multiple Targets Sites. In: S.Lihiri, G.Semenza, N.Prabhak,editors. Oxygen Sensing: Responses and Adaptation to Hypoxia. Marcel Dekker, Inc; 2003. p. 409-420.

Petrosal Ganglion Responses In Vitro: From Entire Ganglion To Single Cell
Autor(es): Alcayaga J, Varas R, Iturriaga R
Año: 2003:671-683.
Ref: Alcayaga J, Varas R, Iturriaga R. Petrosal Ganglion Responses in Vitro: From Entire Ganglion to Single Cell. In: D.Lihiri, G.Semenza, N.Prabhak,editors. Oxygen Sensing: Responses and Adaptation to Hypoxia. Marcel Dekker, Inc; 2003. p. 671-683.

The Excitatory Effects Of Nitric Oxide On Carotid Body Chemoreception Is Blocked By Oligomycin
Autor(es): Iturriaga R, Mosqueira M
Año: 2001:55-60.
Ref: Iturriaga R, Mosqueira M. The Excitatory Effects of Nitric Oxide on Carotid Body Chemoreception Is Blocked by Oligomycin. In: Chi-Sang Poon , Homayoun Kazem,editors. Frontiers in Modeling and Control of Breathing. Kluwer Academic/Plenum Publish; 2001. p. 55-60.

Modulation Of Arterial Chemoreceptor Activity And Its Contribution To The Hypoxic Response
Autor(es): Zapata P., Iturriaga R.
Año: 1997:341-348.
Ref: Zapata P., Iturriaga R.. Modulation of Arterial Chemoreceptor Activity and Its Contribution to the Hypoxic Response. In: El Altiplano, Ciencia y Conciencia en los Andes. 1997. p. 341-348.

Carbonic Anhydrase And Carotid Chemoreception In The Presence And Absence Of Co2-Hco3
Autor(es): Iturriaga R, Lahiri S
Año: 1993:171-176.
Ref: Iturriaga R, Lahiri S. Carbonic Anhydrase and Carotid Chemoreception in the Presence and Absence of Co2-Hco3. In: P.G. Data, H. Acker and S. Lah,editors. Neurobiology and Cell Physiology of Chemoreceptors. Londres,Gran Bretaña: Advance Experimental Medicne a; 1993. p. 171-176.

Carbonic Anhydrase, Cl-Hco3 Exchanger, And Cellular Ph In O2 And Co2 Chemoreception In The Cat Carotid Body In Vitro
Autor(es): Lahiri S, Iturriaga R, Rumsey W, Wilson D, Spergel D
Año: 1993:132-137.
Ref: Lahiri S, Iturriaga R, Rumsey W, Wilson D, Spergel D. Carbonic Anhydrase, Cl-Hco3 Exchanger, and Cellular Ph in O2 and Co2 Chemoreception in the Cat Carotid Body in Vitro. In: D.F. Speck, M.S. Dekin, W.R. R,editors. Respiratory Control: Central and Peripheral Mechanisms. Estados Unidos: The University Press of Kentuc; 1993. p. 132-137.

Effects Of Haloperidol On Carotid Body Chemoreception In Vitro
Autor(es): Morelli L, Iturriaga R, Spergel D, Data P
Año: 1993:295-300.
Ref: Morelli L, Iturriaga R, Spergel D, Data P. Effects of Haloperidol on Carotid Body Chemoreception in Vitro. In: P.G. Data, H. Acker and S. Lah,editors. Neurobiology and Cell Physiology of Chemoreception. Londres,Gran Bretaña: Advances in Experimental Medic; 1993. p. 295-300.

Optical Mesurements Of Microvascular Oxygen Pressure And Intracellular Ph In The Cat Carotid Body: Testing Hypotheses Of 02 Chemoreception
Autor(es): Rumsey W, Iturriaga R, Spergel D, Wilson D, Lahiri S
Año: 1993:197-204.
Ref: Rumsey W, Iturriaga R, Spergel D, Wilson D, Lahiri S. Optical Mesurements of Microvascular Oxygen Pressure and Intracellular Ph in the Cat Carotid Body: Testing Hypotheses of 02 Chemoreception. In: P.G. Data, H. Acker and S. Kah,editors. Neurobiology and Cell Physiology of Chemoreception. Londres,Gran Bretaña: Advancves in Experimental Medi; 1993. p. 197-204.

Role Of Ion Exchangers In The Carotid Body Chemotransduction
Autor(es): Lahiri S, Iturriaga R
Año: 1993:177-182.
Ref: Lahiri S, Iturriaga R. Role of Ion Exchangers in the Carotid Body Chemotransduction. In: Pg. Data, H. Acker and S. Lahi,editors. Neurobiology and Cell Physiology of Chemoreception. Londres,Gran Bretaña: Advances in Experimental Medic; 1993. p. 177-182.

Flow Detection By The Carotid Body
Autor(es): Alcayaga J, Iturriaga R, Zapata P
Año: 1990:254-259.
Ref: Alcayaga J, Iturriaga R, Zapata P. Flow Detection by the Carotid Body. In: Arterial Chemoreception. New York,Estados Unidos: Springer-Verlag; 1990. p. 254-259.

Sección Patentes

  • Síntesis Enantioselectiva Y Purificación Del Ácido 2(S)-Amino-6-Boronohexanoico (Abh) E Intermedios Claves Sintéticos
  • Combinación Farmacéutica Para El Tratamiento Y Prevención De La Hipertensión Arterial Y Disfunción Vascular¿,