UC
FISIOLOGÍA

MORENO MAURO,RICARDO DANIEL

Ricardo Daniel Moreno Mauro Ricardo Daniel Moreno Mauro

Laboratorio:
Mail: Esta dirección de correo electrónico está protegida contra spambots. Usted necesita tener Javascript activado para poder verla.


Profesor Asociado

Unidad de Endocrinología y Reproducción

FISIOLOGÍA,
Facultad de Ciencias Biológicas,
Pontificia Universidad Católica de Chile, Alameda 340, Santiago

Antecedentes Académicos

Doctor (Ciencias Biológicas) , Pontificia Universidad Católica de Chile (1996).
Licenciado (Ciencias Biológicas) , Pontificia Universidad Católica de Chile (1990).

Postdoctorado:

Departamento de Ciencias Fisiológicas, Facultad Ciencias Biológicas, Pontifica Universidad Católica de Chile (Fellow Rockefeller Foundation)(1996-1998)

Especialización:

Oregon Regional Primate Research Center (NIH/Forgathy Fellowship)(1998-2000)Biología Reproductiva: Espermatogénesis, ovogénesis y fecundación

Actividades de Docencia

Pregado
  • 2017 BIO131E-1, Bioetica.
  • 2017 BIO313C-1, Reproduccion Animal.
  • 2017 BIO141C-4, Biologia De La Celula.
Postgrado
  • 2017 BIO4705-1, Topicos De Bioetica.
  • 2017 BIO4141-1, Comunicación Celular.
  • 2017 BIO4141-1, Comunicación Celular.

Líneas de Investigación

Mi investigación está centrada en entender cómo se forma y cómo funciona el espermatozoide de mamífero. En particular, estamos estudiando la dinámica de las moléculas de matriz extracelular y los posibles mecanismos apoptóticos que utilizan las espermatogonias durante el ciclo normal del epitelio seminífero. Nuestra meta última es entender los procesos que regulan la proliferación y diferenciación en las células germinales. Por otro lado, estamos interesados en la biogénesis y función del acrosoma durante la espermatogénesis y fecundación. En este sentido, estamos estudiando cómo se regula el proceso de reacción del acrosoma y algunos parámetros moleculares que puedan ser predictivos de la capacidad fecundante del espermatozoide humano.

Nuestro trabajo tiene una fuerte aplicación en el campo de la infertilidad humana. Sin embargo, también tiene aplicaciones en el mejoramiento o control reproductivo de especies domésticas como el ganado o los perros.


Titulo: Biopsia De Embriones Humanos Antes De Su Implantación
Año: 2015
Concurso e institución: Investigación, UC
Investigador principal: Santos Alcantara Manuel
Otros investigadores: Santos Alcantara Manuel, Moreno Mauro Ricardo Daniel, Alvarado Marambio Jose Tomas Enrique Andres, Ramos Vergara Paulina Cecilia, Hodge Cornejo Cristian Armando
Fecha inicio: 01-03-2015
Fecha termino: 01-12-2015
Duración: 9 meses

Titulo: Mixture Of Endocrine Disruptors (Phtalates And Alkylphenols) Impair Gonadal Function By Regulating Micrornas That Control Sex Steroid Hormone Levels
Año: 2015
Concurso e institución: Regular, CONICYT
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel, Reyes Juan, Marconi Toro Marcelo Carlos
Fecha inicio: 01-03-2015
Fecha termino: 01-03-2019
Duración: 48 meses

Titulo: Involvement Of Tace/adam17 And Pannexin Hemichannels In Xenoestrogens Induced Apoptosis In Mammalian Spermatogenesis
Año: 2011
Concurso e institución: Regular, CONICYT
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel
Fecha inicio: 01-03-2011
Fecha termino: 01-03-2015
Duración: 48 meses

Titulo: Defferential Mechanisms Of Apoptosis Induced By Arachidonic Acid In Pachytene Spermatocytes And Round Spermatids: Role Of Fatty Acid-Sensitive Gpcrs, Pi3K-Akt, Plc And (Ca2+) Signaling Pathways
Año: 2011
Concurso e institución: Regular, CONICYT
Investigador principal: Reyes Juan
Otros investigadores: Reyes Juan, Moreno Mauro Ricardo Daniel
Fecha inicio: 01-03-2011
Fecha termino: 01-03-2014
Duración: 36 meses

Titulo: Desarrollo De Extracto Botánico Contra Células Tumorales Humanas A Partir De Plantas Nativas Chilenas
Año: 2010
Concurso e institución: , Fundación Copec UC
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel, Montenegro Rizzardini Gloria
Fecha inicio: 01-07-2010
Fecha termino: 01-07-2012
Duración: 24 meses

Titulo: El Misterio Del Origen De La Vida
Año: 2010
Concurso e institución: Investigación, UC
Investigador principal: Vigil Portales Maria Del Pilar
Otros investigadores: Vigil Portales Maria Del Pilar, Moreno Mauro Ricardo Daniel, Aguirre Alliende Elena De Lourdes
Fecha inicio: 01-01-2010
Fecha termino: 01-01-2011
Duración: 12 meses

Titulo: Extractos Fenolicos De Recursos Naturales (Miel De Abeja Y Plantas Nativas) Con Propiedades Quimioprotectoras En El Testiculo De Mamifero
Año: 2010
Concurso e institución: Especial, UC
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel, Montenegro Rizzardini Gloria
Fecha inicio: 01-01-2010
Fecha termino: 31-12-2010
Duración: 12 meses

Titulo: Obtención De Nuevos Productos Naturales Bactericidas Contra Patógenos Del Agro Y Humanos A Partir De Plantas Medicinales Chilenas
Año: 2008
Concurso e institución: , Fundación Copec UC
Investigador principal: Montenegro Rizzardini Gloria
Otros investigadores: Montenegro Rizzardini Gloria, Moreno Mauro Ricardo Daniel, Ortega Fuenzalida Ximena Alicia
Fecha inicio: 01-06-2008
Fecha termino: 01-06-2010
Duración: 24 meses

Titulo: Estudio Ultraestructural Y Funcional De La Maduracion Citoplasmatica De Ovocitos Caninos
Año: 2008
Concurso e institución: Regular, CONICYT
Investigador principal: De Los Reyes Solovera Monica
Otros investigadores: De Los Reyes Solovera Monica, Moreno Mauro Ricardo Daniel
Fecha inicio: 01-03-2008
Fecha termino: 01-03-2011
Duración: 36 meses

Titulo: Contribucion De La Proteina Transportadora De Colesterol Npc2 A La Sintesis De Esteroides Y El Desarrollo Folicular En El Ovario
Año: 2007
Concurso e institución: Postdoctorado, CONICYT
Investigador principal: Busso Dolores
Otros investigadores: Busso Dolores, Moreno Mauro Ricardo Daniel
Fecha inicio: 01-11-2007
Fecha termino: 01-11-2009
Duración: 24 meses

Titulo: Modelo In Vitro Para Estudiar El Efecto De La Prolongación Del Tiempo De Exposición En Radioterapia Por Modulación De Intensidad (Imrt)
Año: 2007
Concurso e institución: , Otro
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel, Besa De Carcer Pelayo Francisco
Fecha inicio: 01-05-2007
Fecha termino: 01-05-2008
Duración: 12 meses

Titulo: Papel De La Tace/adam17 En La Apoptosis Dependiente De P53 Durante La Espermatogenesis De Mamiferos.
Año: 2007
Concurso e institución: Regular, CONICYT
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel, Reyes Martinez Juan, Antonelli Anativia Juan
Fecha inicio: 01-03-2007
Fecha termino: 01-03-2011
Duración: 48 meses

Titulo: Relevancia De Las Proteinas Niemann Pick C En Fisiologia Y Fisiopatologia
Año: 2007
Concurso e institución: Regular, CONICYT
Investigador principal: Zanlungo Matsuhiro Silvana
Otros investigadores: Zanlungo Matsuhiro Silvana, Alvarez Rojas Alejandra Beatriz, Castro Salazar Juan Francisco, Moreno Mauro Ricardo Daniel, Rigotti Rivera Attilio Gianpietro
Fecha inicio: 01-03-2007
Fecha termino: 01-03-2011
Duración: 48 meses

Titulo: Regulación Del Número De Espermatogonias Por Muerte Celular Programada: Posible Papel Del C-Kit Y Fas En La Regulación De La Activación De Las Caspasas
Año: 2004
Concurso e institución: Regular, CONICYT
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel, Reyes Martinez Juan
Fecha inicio: 01-03-2004
Fecha termino: 01-03-2007
Duración: 36 meses

Titulo: Regulación Del Número De Espermatogonias Por Muerte Celular Programada: Posible Papel Del C-Kit Y Fas En La Regulación De La Activación De Las Caspasas
Año: 2004
Concurso e institución: Incentivo A La Cooperación Internacional, CONICYT
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel, Kierszenbaum Abraham Leon
Fecha inicio: 01-03-2004
Fecha termino: 01-03-2005
Duración: 12 meses

Titulo: Estudio De Ovocitos Y Espermatozoides Caninos Y Su Relacion Con La Fecundacion In Vitro
Año: 2003
Concurso e institución: Regular, CONICYT
Investigador principal: De Los Reyes Solovera Monica
Otros investigadores: De Los Reyes Solovera Monica, Moreno Mauro Ricardo Daniel
Fecha inicio: 10-03-2003
Fecha termino: 01-03-2005
Duración: 24 meses

Titulo: Papel Del Cito-Esqueleto De Microtúbulos En La Formación Del Acrosoma De Mamíferos
Año: 2001
Concurso e institución: Inicio, UC
Investigador principal: Moreno Mauro Ricardo Daniel
Otros investigadores: Moreno Mauro Ricardo Daniel
Fecha inicio: 01-01-2001
Fecha termino: 01-01-2003
Duración: 24 meses


Publicaciones ISI

1
Effects Of Ascorbic Acid On Spermatogenesis And Sperm Parameters In Diabetic Rats
Autor(es): Aguirre M, Velarde V, Moreno R
Año: 2017.370:305-317.
Ref: Aguirre M, Velarde V, Moreno R. Effects of ascorbic acid on spermatogenesis and sperm parameters in diabetic rats. Cell And Tissue Research. 2017;370(2):305-317.

2
Effects Of Fatty Acids On Intracellular [Ca2+], Mitochondrial Uncoupling And Apoptosis In Rat Pachytene Spermatocytes And Round Spermatids
Autor(es): Paillamanque J , Madrid C, Carmona E, Osses N , Moreno R, Oresti G, Pino J, Reyes J
Año: 2016.11:1-20.
Ref: Paillamanque J , Madrid C, Carmona E, Osses N , Moreno R, Oresti G, Pino J, Reyes J. Effects of Fatty Acids on Intracellular [Ca2+], Mitochondrial Uncoupling and Apoptosis in Rat Pachytene Spermatocytes and Round Spermatids. Plos One. 2016;11(7):1-20.

3
Mitotic Inheritance Of Mrna Facilitates Translational Activation Of The Osteogenic-Lineage Commitment Factor Runx2 In Progeny Of Osteoblastic Cells
Autor(es): Lizama C, Moreno R, Varela N, Aranguiz A, Sepulveda H, Antonelli M, Thaler R, Montecino M, Stein G, Van Wijnen A, Galindo M
Año: 2016.231:1001-1014.
Ref: Lizama C, Moreno R, Varela N, Aranguiz A, Sepulveda H, Antonelli M, Thaler R, Montecino M, Stein G, Van Wijnen A, Galindo M. Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells. Journal Of Cellular Physiology. 2016;231(5):1001-1014.

4
2-Hydroxyoestradiol And 2-Methoxyoestradiol, Two Endogenous Oestradiol Metabolites, Induce Dna Fragmentation In Sertoli Cells
Autor(es): Valencia C, Molina C, Florez M, Bunay J, Moreno R, Orihuela P, Castro A, Parada A
Año: 2016.48:1294-1306.
Ref: Valencia C, Molina C, Florez M, Bunay J, Moreno R, Orihuela P, Castro A, Parada A. 2-hydroxyoestradiol and 2-methoxyoestradiol, two endogenous oestradiol metabolites, induce DNA fragmentation in Sertoli cells. Andrologia. 2016;48(10):1294-1306.

5
In Vitro Fertilization (Ivf) In Mammals: Epigenetic And Developmental Alterations. Scientific And Bioethical Implications For Ivf In Humans
Autor(es): Ventura P, Irarrazaval I, Rolle A, Gutierrez J, Moreno R, Santos M
Año: 2015.48:---.
Ref: Ventura P, Irarrazaval I, Rolle A, Gutierrez J, Moreno R, Santos M. In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans. Biological Research. 2015;48(UNSP 68):---.

6
Involvement Of A P2X7 Receptor In The Acrosome Reaction Induced By Atp In Rat Spermatozoa
Autor(es): Torres J, Rios M, Moreno R
Año: 2015.230:3068-3075.
Ref: Torres J, Rios M, Moreno R. Involvement of a P2X7 Receptor in the Acrosome Reaction Induced by ATP in Rat Spermatozoa. Journal Of Cellular Physiology. 2015;230(12):3068-3075.

7
A Mechanism Of Male Germ Cell Apoptosis Induced By Bisphenol-A And Nonylphenol Involving Adam17 And P38 Mapk Activation
Autor(es): Urriola-Munoz P, Lagos-Cabre R, Moreno R
Año: 2014.9:1-27.
Ref: Urriola-Muñoz P, Lagos-Cabré R, Moreno R. A mechanism of male germ cell apoptosis induced by bisphenol-A and nonylphenol involving ADAM17 and p38 MAPK activation. Plos One. 2014;9(12):1-27.

8
Spermatozoa From Mice Deficient In Niemann-Pick Disease Type C2 (Npc2) Protein Have Defective Cholesterol Content And Reduced In Vitro Fertilising Ability
Autor(es): Busso D, Onate-Alvarado M, Balboa E, Castro J, Lizama C, Morales G, Zanlungo S, Vargas S, Moreno R, Hartel S
Año: 2014.26:609-621.
Ref: Busso D, Oñate-Alvarado M, Balboa E, Castro J, Lizama C, Morales G, Zanlungo S, Vargas S, Moreno R, Härtel S. Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability. Reproduction Fertility And Development. 2014;26(4):609-621.

9
Differential Expression And Localization Of Adam10 And Adam17 During Rat Spermatogenesis Suggest A Role In Germ Cell Differentiation
Autor(es): Urriola-Munoz P, Lizama C, Lagos R, Moreno R, Reyes J
Año: 2014.47:1-12.
Ref: Urriola-Munoz P, Lizama C, Lagos R, Moreno R, Reyes J. Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation. Biological Research. 2014;47:1-12.

10
Differential Effects Of Temperature On Reactive Oxygen/nitrogen Species Production In Rat Pachytene Spermatocytes And Round Spermatids
Autor(es): Pino J, Osses N, Oyarzun D, Farias J, Moreno R, Reyes J
Año: 2013.145:203-212.
Ref: Pino J, Osses N, Oyarzun D, Farias J, Moreno R, Reyes J. Differential effects of temperature on reactive oxygen/nitrogen species production in rat pachytene spermatocytes and round spermatids. Reproduction. 2013;145(2):203-212.

11
Concanavalin-A Induces Granulosa Cell Death And Inhibits Fsh-Mediated Follicular Growth And Ovarian Maturation In Female Rats
Autor(es): Velasquez E, Rios M, Ortiz M, Lizama C, Nunez E, Abramovich D, Orge F, Oliva B, Orellana R, Villalon M, Moreno R, Owen G, Et Al.
Año: 2013.154:1885-1896.
Ref: Velasquez E, Rios M, Ortiz M, Lizama C, Nunez E, Abramovich D, Orge F, Oliva B, Orellana R, Villalon M, Moreno R, Owen G, et al.. Concanavalin-A Induces Granulosa Cell Death and Inhibits FSH-Mediated Follicular Growth and Ovarian Maturation in Female Rats. Endocrinology. 2013;154(5):1885-1896.

12
Contribution Of Environmental Pollutants To Male Infertily: A Working Model Of Germ Cell Apoptosis Induced By Plasticizers
Autor(es): Lagos R , Moreno R
Año: 2012.45:5-14.
Ref: Lagos R , Moreno R. Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers. Biological Research. 2012;45(1):5-14.

13
Apoptosis, Necrosis And Autophagy Are Influenced By Metabolic Energy Sources In Cultured Rat Spermatocytes
Autor(es): Bustamante X , Quiroga C , Lavandero S , Reyes J, Moreno R
Año: 2012.17:539-550.
Ref: Bustamante X , Quiroga C , Lavandero S , Reyes J, Moreno R. Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes. Apoptosis. 2012;17(6):539-550.

14
Involvement Of Tace/adam17 And Adam10 In Etoposide-Induced Apoptosis Of Germ Cells In Rat Spermatogenesis
Autor(es): Lizama C, Rojas D , Antonelli M , Ludwig A, Moreno R
Año: 2012.227:829-838.
Ref: Lizama C, Rojas D , Antonelli M , Ludwig A, Moreno R. Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis. Journal Of Cellular Physiology. 2012;227(2):829-838.

15
Involvement Of Tace/adam17 And Adam10 In Etoposide-Induced Apoptosis Of Germ Cells In Rat Spermatogenesi
Autor(es): Lizama C, Rojas-Benitez D, Antonelli M, Moreno Rd
Año: 2012.227:829-238.
Ref: Lizama C, Rojas-Benitez D, Antonelli M, Moreno RD. Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesi. Journal Of Cellular Physiology. 2012;227(2):829-238.

16
Golgi Apparatus And Endoplasmic Reticulum Dynamic During Meiotic Development In Canine Oocytes
Autor(es): De Los Reyes M, Palomino J, Jofre S, Villarroel A, Moreno R
Año: 2012.47:93-97.
Ref: De los Reyes M, Palomino J, Jofre S, Villarroel A, Moreno R. Golgi Apparatus and Endoplasmic Reticulum Dynamic during Meiotic Development in Canine Oocytes. Reproduction In Domestic Animals. 2012;47(SUPPL. 6):93-97.

17
The Hypoxic Testicle: Physiology And Pathophysiology
Autor(es): Reyes J, Farias J, Henriquez S, Madrid E, Parraga M, Zepeda A, Moreno R
Año: 2012.2012:Art. 929285-..
Ref: Reyes J, Farias J, Henriquez S, Madrid E, Parraga M, Zepeda A, Moreno R. The hypoxic testicle: Physiology and pathophysiology. Oxidative Medicine and Cellular Longevity . 2012;2012:Art. 929285-..

18
Propylthiouracil-Induced Hypothyroidism Delays Apoptosis During The First Wave Of Spermatogenesis
Autor(es): Silva D , Lizama C , Tapia V , Moreno R
Año: 2011.44:181-188.
Ref: Silva D , Lizama C , Tapia V , Moreno R. Propylthiouracil-induced hypothyroidism delays apoptosis during the first wave of spermatogenesis. Biological Research. 2011;44(2):181-188.

19
Protease Activity Involvement In The Passage Of Mammalian Sperm Through The Zona Pellucida
Autor(es): Moreno R , Laserre A, Barros C
Año: 2011.44:145-150.
Ref: Moreno R , Laserre A, Barros C . Protease activity involvement in the passage of mammalian sperm through the zona pellucida. Biological Research. 2011;44(2):145-150.

20
Expression Of Bcl-2 Family Genes In Germ Cells Undergoing Apoptosis During The First Wave Of Spermatogenesis In The Rat
Autor(es): Vergara S, Lizama C , Brouwer J , Moreno R
Año: 2011.43:242-247.
Ref: Vergara S, Lizama C , Brouwer J , Moreno R. Expression of BCL-2 family genes in germ cells undergoing apoptosis during the first wave of spermatogenesis in the rat. Andrologia. 2011;43(4):242-247.

21
Etoposide Induces Apoptosis And Upregulation Of Tace/adam17 And Adam10 In An In Vitro Male Germ Cell Line Model
Autor(es): Lizama C , Ludwig A , Moreno R
Año: 2011.1813:120-128.
Ref: Lizama C , Ludwig A , Moreno R . Etoposide induces apoptosis and upregulation of TACE/ADAM17 and ADAM10 in an in vitro male germ cell line model. Biochimica Et Biophysica Acta-Molecular Cell Research. 2011;1813(1):120-128.

22
Tace/adam17 Is Involved In Germ Cell Apoptosis During Rat Spermatogenesis
Autor(es): Lizama C, Rojas-Benitez D, Antonelli M, Ludwig A, Bustamante-Marin X, Brouwer-Visser J, Moreno Rd
Año: 2010.140:305-317.
Ref: Lizama C, Rojas-Benítez D, Antonelli M, Ludwig A, Bustamante-Marín X, Brouwer-Visser J, Moreno RD. TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis. Reproduction. 2010;140(2):305-317.

23
Life-Giving Caspases: Revealing New Roles During Mouse Embryo Preimplantation Development
Autor(es): Busso D, Dominguez C, Perez-Acle T, Moreno Rd
Año: 2010.54:857-865.
Ref: Busso D, Domínguez C, Pérez-Acle T, Moreno RD. Life-giving caspases: revealing new roles during mouse embryo preimplantation development. International Journal Of Developmental Biology. 2010;54(5):857-865.

24
P73 Participates In Male Germ Cells Apoptosis Induced By Etoposide
Autor(es): Codelia Va, Cisterna M, Alvarez Ar, Moreno Rd
Año: 2010.16:734-742.
Ref: Codelia VA, Cisterna M, Alvarez AR, Moreno RD. p73 participates in male germ cells apoptosis induced by etoposide. Molecular Human Reproduction. 2010;16(10):734-742.

25
Female Infertility Due To Anovulation And Defective Steroidogenesis In Npc2 Deficient Mice
Autor(es): Busso D, Onate-Alvarado Mj, Balboa E, Zanlungo S, Moreno Rd
Año: 2010.315:299-307.
Ref: Busso D, Oñate-Alvarado MJ, Balboa E, Zanlungo S, Moreno RD. Female infertility due to anovulation and defective steroidogenesis in NPC2 deficient mice. Molecular And Cellular Endocrinology. 2010;315(1-2):299-307.

26
Differential Localization Of Alpha' And Beta Subunits Of Protein Kinase Ck2 During Rat Spermatogenesis
Autor(es): Alvarado-Diaz Cp, Tapia Jc, Antonelli M, Moreno Rd
Año: 2009.338:139-149.
Ref: Alvarado-Díaz CP, Tapia JC, Antonelli M, Moreno RD. Differential localization of alpha' and beta subunits of protein kinase CK2 during rat spermatogenesis. Cell And Tissue Research. 2009;338(1):139-149.

27
A Molecular Evaluation Of Germ Cell Death Induced By Etoposide In Pubertal Rat Testes
Autor(es): Ortiz Rj, Lizama C, Codelia Va, Moreno Rd
Año: 2009.15:363-371.
Ref: Ortíz RJ, Lizama C, Codelia VA, Moreno RD. A molecular evaluation of germ cell death induced by etoposide in pubertal rat testes. Molecular Human Reproduction. 2009;15(6):363-371.

28
Informe Para El Tribunal Constitucional Sobre Los Aspectos Científicos Y Éticos Del Uso Del Levonorgestrel Como Anticonceptivo De Emergencia
Autor(es): Ventura-Junca P, Williamson C, Grebe G, Sanchez I, Oyarzun E, Taboada P, Barros C, Santos Mj, Moreno R, Besio M
Año: 2009.:17-40.
Ref: ventura-juncá p, williamson c, Grebe g, Sanchez i, oyarzun e, taboada p, barros c, santos mj, moreno r, besio m. Informe para el Tribunal Constitucional sobre los aspectos científicos y éticos del uso del Levonorgestrel como anticonceptivo de emergencia. Ars Medica. 2009;(17):17-40.

29
Calpain Inhibitors Prevent P38 Mapk Activation And Germ Cell Apoptosis After Heat Stress In Pubertal Rat Testes
Autor(es): Lizama C, Lagos C, Lagos-Cabre R, Cantuarias L, Rivera F, Huenchunir P, Perez-Acle T, Carrion F, Moreno Rd
Año: 2009.221:296-305.
Ref: Lizama C, Lagos C, Lagos-Cabre R, Cantuarias L, Rivera F, Huenchuñir P, Pérez-Acle T, Carrion F, Moreno RD. Calpain Inhibitors Prevent p38 MAPK Activation and Germ Cell Apoptosis After Heat Stress in Pubertal Rat Testes. Journal Of Cellular Physiology. 2009;221(2):296-305.

30
Mitotic, But Not Meiotic, Oriented Cell Divisions In Rat Spermatogenesis
Autor(es): Lagos-Cabre, R, Moreno Rd
Año: 2008.135:471-478.
Ref: Lagos-Cabré, R, Moreno RD. Mitotic, but not meiotic, oriented cell divisions in rat spermatogenesis. Reproduction. 2008;135(4):471-478.

31
Relevance Of Caspase Activity During Apoptosis In Pubertal Rat Spermatogenesis
Autor(es): Codelia V, Cisternas P, Moreno R
Año: 2008.75:881-889.
Ref: Codelia V, Cisternas P, Moreno R. Relevance of caspase activity during apoptosis in pubertal rat spermatogenesis. Molecular Reproduction And Development. 2008;75(5):881-889.

32
Up-Regulation Of Cd95 (Apo-1/fas) Is Associated With Spermatocyte Apoptosis During The First Round Of Spermatogenesis In The Rat
Autor(es): Lizama C, Alfaro I, Reyes J, Moreno R
Año: 2007.12:499-512.
Ref: Lizama C, Alfaro I, Reyes J, Moreno R. Up-regulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat. Apoptosis. 2007;12(3):499-512.

33
Caspase Activation Throughout The First Wave Of Spermatogenesis In The Rat
Autor(es): Moreno R, Lizama C, Urzua N, Vergara S, Reyes J
Año: 2006.325:533-540.
Ref: Moreno R, Lizama C, Urzúa N, Vergara S, Reyes J. Caspase Activation Throughout the First Wave of Spermatogenesis in the Rat. Cell And Tissue Research. 2006;325(3):533-540.

34
The Mammalian Acrosome As A Secretory Lysosome: New And Old Evidence
Autor(es): Moreno R
Año: 2006.73:1430-1434.
Ref: Moreno R. The Mammalian Acrosome As a Secretory Lysosome: New and Old Evidence. Molecular Reproduction And Development. 2006;73(11):1430-1434.

35
Proacrosin/acrosin Quantification As An Indicator Of Acrosomal Integrity In Fresh And Frozen Dog Spermatozoa
Autor(es): Cortes Cj, Codelia Va, Manosalva I, De Lange J, De Los Reyes M, Moreno Rd
Año: 2006.93:165-175.
Ref: Cortes CJ, Codelia VA, Manosalva I, de Lange J, De los Reyes M, Moreno RD. Proacrosin/acrosin quantification as an indicator of acrosomal integrity in fresh and frozen dog spermatozoa. Animal Reproduction Science. 2006;93(1-2):165-175.

36
Comparative Analysis Of Apoptotic Pathways In Rat, Mouse, And Hamster Spermatozoa
Autor(es): Cisternas P, Moreno R
Año: 2006.73:1318-1325.
Ref: Cisternas P, Moreno R. Comparative Analysis of Apoptotic Pathways in Rat, Mouse, and Hamster Spermatozoa. Molecular Reproduction And Development. 2006;73(10):1318-1325.

37
Assembly Of Spermatid Acrosome Depends On Microtubule Organization
Autor(es): Moreno R, Palomino J, Schatten G
Año: 2006.293:218-227.
Ref: Moreno R, Palomino J, Schatten G. Assembly of Spermatid Acrosome Depends on Microtubule Organization. Developmental Biology. 2006;293(1):218-227.

38
Inhibition Of The Vacuolar H(+)-Pump With Bafilomycin A1 Does Not Induce Acrosome Reaction Or Activate Proacrosin In Mouse Spermatozoa
Autor(es): Codelia V, Cortes C, Moreno R
Año: 2005.337:1337-1344.
Ref: Codelia V, Cortés C, Moreno R. Inhibition of the Vacuolar H(+)-Pump With Bafilomycin A1 Does Not Induce Acrosome Reaction or Activate Proacrosin in Mouse Spermatozoa. Biochemical And Biophysical Research Communications. 2005;337(4):1337-1344.

39
Differential Expression Of Lysosomal Associated Membrane Protein (Lamp-1) During Mammalian Spermiogenesis
Autor(es): Moreno R
Año: 2003.66:202-209.
Ref: Moreno R. Differential Expression of Lysosomal Associated Membrane Protein (Lamp-1) During Mammalian Spermiogenesis. Molecular Reproduction And Development. 2003;66(2):202-209.

40
Inhibition Of Mouse In Vitro Fertilization By An Antibody Against A Unique 18-Amino Acid Domain In The Polysulfate-Binding Fomain Of Proacrosin/acrosin
Autor(es): Moreno R, Bustamante E, Schatten G, Barros F
Año: 2002.77:812-816.
Ref: Moreno R, Bustamante E, Schatten G, Barros F. Inhibition of Mouse in Vitro Fertilization by An Antibody Against a Unique 18-Amino Acid Domain in the Polysulfate-Binding Fomain of Proacrosin/Acrosin. Fertility And Sterility. 2002;77(4):812-816.

41
Golgi Apparatus Dynamics During Mouse Oocyte In Vitro Maturation: Effect Of The Membrane Trafficking Inhibitor Brefeldin A1
Autor(es): Moreno R, Schattem G, Ramalho J
Año: 2002.66:1259-1266.
Ref: Moreno R, Schattem G, Ramalho J. Golgi Apparatus Dynamics During Mouse Oocyte in Vitro Maturation: Effect of the Membrane Trafficking Inhibitor Brefeldin A1. Biology Of Reproduction. 2002;66(5):1259-1266.

42
Control Of Membrane Fusion During Spermiogenesis And The Acrosome Reaction
Autor(es): Ramalho J, Schatten G, Moreno R
Año: 2002.67:1043-1051.
Ref: Ramalho J, Schatten G, Moreno R. Control of Membrane Fusion During Spermiogenesis and the Acrosome Reaction. Biology Of Reproduction. 2002;67(4):1043-1051.

43
Egg Coats Of The Rock Shrimp Rhynchocinetes Typus: Ultrastructural Characterization And Their Function During Fertilization
Autor(es): Palomino J, Moreno R, Bustamante E, Messen L, Dupre E, Barros F
Año: 2002.293:632-640.
Ref: Palomino J, Moreno R, Bustamante E, Messen L, Dupre E, Barros F. Egg Coats of the Rock Shrimp Rhynchocinetes Typus: Ultrastructural Characterization and Their Function During Fertilization. Journal Of Experimental Zoology. 2002;293(6):632-640.

44
Purification And Biochemical Characterization Of A Trypsin-Like Enzyme Present In The Sperm Of The Rock Shrimp, Rhynchocinetes Typus
Autor(es): Bustamante E, Palomino J, Amoroso A, Moreno R, Barros F
Año: 2001.39:175-181.
Ref: Bustamante E, Palomino J, Amoroso A, Moreno R, Barros F. Purification and Biochemical Characterization of a Trypsin-Like Enzyme Present in the Sperm of the Rock Shrimp, Rhynchocinetes Typus. Invertebrate Reproduction & Development. 2001;39(3):175-181.

45
A Putative, Ubiquin-Dependent Mechanism For The Recognition And Elimination Of Defective Spermatozoa In The Mammalian Epididymis
Autor(es): Sutovski P, Moreno R, Ramalho-Santos J, Dominko T, Thompson W, Schatten G
Año: 2001.114:1665-1675.
Ref: Sutovski P, Moreno R, Ramalho-Santos J, Dominko T, Thompson W, Schatten G. A Putative, Ubiquin-Dependent Mechanism for the Recognition and Elimination of Defective Spermatozoa in the Mammalian Epididymis. Journal Of Cell Science. 2001;114(9):1665-1675.

46
Targeting And Fusion Proteins During Mammalian Spermiogenesis
Autor(es): Ramalho-Santos J, Moreno R
Año: 2001.34:147-152.
Ref: Ramalho-Santos J, Moreno R. Targeting and Fusion Proteins During Mammalian Spermiogenesis. Biological Research. 2001;34(2):147-152.

47
Membrane Trafficking Machinery Components Associated With The Mammalian Acrosome During Spermiogenesis
Autor(es): Ramalho-Santos J, Moreno R, Wessel G, Chan E, Schatten G
Año: 2001.267:45-60.
Ref: Ramalho-Santos J, Moreno R, Wessel G, Chan E, Schatten G. Membrane Trafficking Machinery Components Associated With the Mammalian Acrosome During Spermiogenesis. Experimental Cell Research. 2001;267(1):45-60.

48
Differential Effects Of Polysulphates Between Mouse And Hamster During In Vitro Fertilization
Autor(es): Moreno R, Orihuela P, Barros F
Año: 2001.33:19-25.
Ref: Moreno R, Orihuela P, Barros F. Differential Effects of Polysulphates Between Mouse and Hamster During in Vitro Fertilization. Andrologia. 2001;33(1):19-25.

49
Vesicular Traffic And Golgi Apparatus Dynamics During Mammalian Spermatogenesis: Implications For Acrosome Architecture
Autor(es): Moreno R, Ramalho-Santos J, Sutovsky P, Chan E, Schatten G
Año: 2000.63:89-98.
Ref: Moreno R, Ramalho-Santos J, Sutovsky P, Chan E, Schatten G. Vesicular Traffic and Golgi Apparatus Dynamics During Mammalian Spermatogenesis: Implications for Acrosome Architecture. Biology Of Reproduction. 2000;63(1):89-98.

50
A Basic 18- Amino Acid Peptide Contains The Polysulfate-Binding Domain Responsible For Activation Of The Boar Proacrosin/ Acrosin Syst
Autor(es): Moreno R, Barros F
Año: 2000.62:1536-1542.
Ref: Moreno R, Barros F. A Basic 18- Amino Acid Peptide Contains the Polysulfate-Binding Domain Responsible for Activation of the Boar Proacrosin/ Acrosin Syst. Biology Of Reproduction. 2000;62(6):1536-1542.

51
Snares In Mammalian Sperm : Possible Implications For Fertilization
Autor(es): Ramalho-Santos J, Moreno R, Sutovsky P, Chan Wing-Sang A, Hewitson L, Wessel G, Simerly C, Schatten G
Año: 2000.223:54-69.
Ref: Ramalho-Santos J, Moreno R, Sutovsky P, Chan Wing-Sang A, Hewitson L, Wessel G, Simerly C, Schatten G. Snares in Mammalian Sperm : Possible Implications for Fertilization. Developmental Biology. 2000;223(1):54-69.

52
Ubiquitinated Sperm Mitochondria, Selective Proteolysis, And The Regulation Of Mitochondrial Inheritance In Ammalian Embryos
Autor(es): Sutovsky P, Moreno Rd, Ramalho J, Dominko T, Simerly C, Schatten G
Año: 2000.63:582-592.
Ref: Sutovsky P, Moreno RD, Ramalho J, Dominko T, Simerly C, Schatten G. Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in ammalian embryos. Biology Of Reproduction. 2000;63(2):582-592.

53
The Golgi Apparatus Segregates From The Lysosomal/acrosomal Vesicle During Rhesus Spermiogenesis: Structural Alterations
Autor(es): Moreno Rd, Ramalho-Santos J, Chan Ek, Wessel Gm, Schatten G
Año: 2000.219:334-349.10.1006/dbio.20
Ref: Moreno RD, Ramalho-Santos J, Chan EK, Wessel GM, Schatten G. The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: structural alterations. Developmental Biology. 2000;219(2):334-349.

54
Functional Interactions Between Sulphated Polisaccharides And Proacrosin: Implications In Sperm Binding And Digestion Of Zona Pellucida
Autor(es): Moreno R, Hoshi M, Barros F
Año: 1999.7:105-111.
Ref: Moreno R, Hoshi M, Barros F. Functional Interactions Between Sulphated Polisaccharides and Proacrosin: Implications in Sperm Binding and Digestion of Zona Pellucida. Zygote. 1999;7(2):105-111.

55
The Polysulphate Binding Domain Of Human Proacrosin/acrosin Is Involved In Both The Enzyme Activation And Spermatozoa-Zona Pellucida Interaction
Autor(es): Moreno R, Sepulveda M, De Ioannes A, Barros F
Año: 1998.6:75-83.
Ref: Moreno R, Sepúlveda M, De Ioannes A, Barros F. The Polysulphate Binding Domain of Human Proacrosin/Acrosin Is Involved in Both the Enzyme Activation and Spermatozoa-Zona Pellucida Interaction. Zygote. 1998;6(1):75-83.

56
Developmental Regulation Of Mouse Brain Monomeric Acetylcholinesterase
Autor(es): Moreno R, Campos E, Dajas F, Moreno R, Campos F, Inestrosa N
Año: 1998.16:123-134.
Ref: Moreno R, Campos E, Dajas F, Moreno R, Campos F, Inestrosa N. Developmental Regulation of Mouse Brain Monomeric Acetylcholinesterase. International Journal Of Developmental Neuroscience. 1998;16(2):123-134.

57
Acetylcholinesterase Accelerates Assembly Of Amyloid-B-Peptides Into Alzheimer's Fibrils: Possible Role Of The Peripheral Site Of The Enzyme
Autor(es): Inestrosa N, Alvarez A, Perez C, Moreno R, Vicente M, Linker C, Casanueva O, Soto C, Garrido J
Año: 1996.16:881-891.
Ref: Inestrosa N, Álvarez A, Pérez C, Moreno R, Vicente M, Linker C, Casanueva O, Soto C, Garrido J. Acetylcholinesterase Accelerates Assembly of Amyloid-B-Peptides Into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme. Neuron. 1996;16(4):881-891.

58
Sprouting And Abnormal Contacts Of Nonmedullated Axons, And Deposition Of Extracellular Material Induced By The Amyloid Precursor Protein (App) And Other Protease Inhibitors
Autor(es): Moreno R, Inestrosa N, Culwell A, Alvarez J
Año: 1996.718:13-24.
Ref: Moreno R, Inestrosa N, Culwell A, Álvarez J. Sprouting and Abnormal Contacts of Nonmedullated Axons, and Deposition of Extracellular Material Induced by the Amyloid Precursor Protein (App) and Other Protease Inhibitors. Brain Research. 1996;718(1-2):13-24.

59
Tetrametric (G4) Acetylcholinesterase: Structure, Localization, And Physiological Regulation
Autor(es): Fernandez H, Moreno R, Inestrosa N
Año: 1996.66:1335-1346.
Ref: Fernández H, Moreno R, Inestrosa N. Tetrametric (G4) Acetylcholinesterase: Structure, Localization, and Physiological Regulation. Journal Of Neurochemistry. 1996;66(4):1335-1346.

60
Mitosis Of Schwann Cells And Demyelination Are Induced By The Amyloid Precursor Protein And Other Protease Iñnhibitors In The Rat Sciatic Nerve
Autor(es): Alvarez J, Moreno R, Inestrosa N
Año: 1995.7:152-159.
Ref: Álvarez J, Moreno R, Inestrosa N. Mitosis of Schwann Cells and Demyelination Are Induced by the Amyloid Precursor Protein and Other Protease Iñnhibitors in the Rat Sciatic Nerve. European Journal Of Neuroscience. 1995;7(1):152-159.

61
Monomeric Amphiphilic Forms Of Acetycholinesterase Apperar Early During Brain Development And May Correspond To Biosynthetic Precursors Of The Amphiphilic G4 Forms
Autor(es): Inestrosa N, Moreno R, Fuentes M
Año: 1994.173:155-158.
Ref: Inestrosa N, Moreno R, Fuentes M. Monomeric Amphiphilic Forms of Acetycholinesterase Apperar Early During Brain Development and May Correspond to Biosynthetic Precursors of the Amphiphilic G4 Forms. Neuroscience Letters. 1994;173:155-158.



Libros y Capitulos de Libros


Biologa 2
Autor(es): Quintanilla M, Santos M, Moreno R, Pino M, Ravanal E, Rodriguez L, Soto F
Año: 2007:-350.
Ref: Quintanilla M, Santos M, Moreno R, Pino M, Ravanal E, Rodríguez L, Soto F. Biología 2. 2007. Vilches L,editors. Santiago de Chile: Arrayán; 2007.

Polychaeta
Autor(es): Rozbaczylo N, Moreno Rd
Año: 2006:175-178.
Ref: Rozbaczylo N, Moreno RD. Polychaeta. In: P. Saball, M.T.K. Arroyo, J.C. Castilla, C. Estades, J.M. Ladrón Guevara, S. Larraín, C.A. Moreno, F,editors. Biodiversidad de Chile Patrimonio y Desafíos. Santiago: Ocho Libros Editores Ltda.; 2006. p. 175-178.